Ranklev E, Monti M, Fletcher R
Br J Anaesth. 1985 Oct;57(10):991-3. doi: 10.1093/bja/57.10.991.
In an attempt to develop a diagnostic test for malignant hyperpyrexia (MH) without the need for open muscle biopsy, we have investigated the change in heat production brought about when platelets and muscle are exposed to halothane and caffeine. Halothane 3% caused platelet aggregation, which was itself associated with heat production. Caffeine 4 mmol litre-1 decreased heat production in platelets from both MH susceptible and non-susceptible individuals. Muscle exposed to 4% halothane showed an increase in heat production in both types of tissue. There were no significant differences in heat production between MH-susceptible and non-susceptible tissue in any of the tests.
为了开发一种无需进行开放性肌肉活检的恶性高热（MH）诊断测试，我们研究了血小板和肌肉暴露于氟烷和咖啡因时产生的热量变化。3%的氟烷会导致血小板聚集，而血小板聚集本身会产生热量。4 mmol/L的咖啡因可降低MH易感个体和非易感个体血小板的产热。暴露于4%氟烷的肌肉在两种组织类型中均显示产热增加。在任何测试中，MH易感组织和非易感组织之间的产热均无显著差异。
