Rodríguez-Goncer Isabel, Ruiz-Arabi Elisa, Herrera Sabina, Sabé Nuria, Los-Arcos Ibai, Silva José Tiago, Pérez-Nadales Elena, Machuca Isabel, Álvarez Rocío, Valerio Maricela, Castón Juan José, Aguilera Victoria, Bodro Marta, Cano Ángela, Cantón Rafael, Carmona Purificación, Carratalà Jordi, Cordero Elisa, Cruzado Josep María, Fariñas María Carmen, Fernández-Ruiz Mario, Fondevila Constantino, Fortún Jesús, García-Cosío M Dolores, Gutiérrez-Dalmau Alex, Iturbe David, Justo Iago, Len Oscar, López-Medrano Francisco, López Oliva María Ovidia, Martín-Dávila Pilar, Martínez-Martínez Luis, Mazuecos Auxiliadora, Mirabet Sonia, Muñoz Patricia, Oliver Antonio, Pérez-Sáez María José, Rodríguez-Gómez Jorge, San-Juan Rafael, Sánchez-Céspedes Javier, Solé Amparo, Vidal Verdú Elisa, Villa Jennifer, Torre-Cisneros Julián, Aguado José María
Unit of Infectious Diseases, University Hospital "12 de Octubre", Biomedical Research Institute Hospital "12 de Octubre" (i+12), Madrid, Spain; Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain; School of Medicine, Universidad Complutense, Madrid, Spain.
Center for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Instituto de Salud Carlos III, Spain; Service of Infectious Diseases, Reina Sofia University Hospital, Spain; Maimonides Institute for Biomedical Research (IMIBIC), University of Cordoba, Cordoba, Spain.
Transplant Rev (Orlando). 2025 Jul;39(3):100937. doi: 10.1016/j.trre.2025.100937. Epub 2025 May 21.
Multidrug-resistant (MDR) Gram-negative bacilli (GNB) infections in solid organ transplant (SOT) recipients continue to pose a significant threat despite advances in diagnostics and treatments. The last international consensus guidelines of the Spanish Society of Infectious Diseases and Clinical Microbiology (SEIMC) on the management of MDR GNB in adult solid organ transplant (SOT) recipients were published in 2018, underscoring the need for an update to incorporate recent advances, particularly the availability of new drugs that may improve the current standard of care. A working group consisting of members from the Study Group of Infection in Transplantation and Immunocompromised Hosts (GESITRA-IC) of SEIMC, the Center for Biomedical Research Network in Infectious Diseases (CIBERINFEC) and the Spanish Society of Transplantation (SET) developed consensus-based recommendations for managing MDR GNB infections during the transplant procedure. Recommendations were categorized based on evidence quality and strength, utilizing the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. The final recommendations were endorsed through a consensus meeting and approved by the expert panel.
尽管在诊断和治疗方面取得了进展，但实体器官移植（SOT）受者中的多重耐药（MDR）革兰氏阴性杆菌（GNB）感染仍然构成重大威胁。西班牙传染病和临床微生物学会（SEIMC）关于成人实体器官移植（SOT）受者中MDR GNB管理的最新国际共识指南于2018年发布，强调需要更新以纳入最新进展，特别是可能改善当前护理标准的新药的可用性。一个由SEIMC移植和免疫受损宿主感染研究组（GESITRA-IC）、传染病生物医学研究网络中心（CIBERINFEC）和西班牙移植学会（SET）成员组成的工作组制定了基于共识的移植过程中MDR GNB感染管理建议。建议根据证据质量和强度进行分类，采用推荐分级评估、制定和评价（GRADE）系统。最终建议通过共识会议得到认可，并由专家小组批准。
