慢性肾脏病患者的心肺运动试验
Cardiopulmonary Exercise Testing in Patients with Chronic Kidney Disease.
作者信息
Groninger Nolan W, Dillman Drake E, Stafford Hunter, Campos Monique, Coggan Andrew R, Lim Kenneth
机构信息
Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA,
Division of Nephrology and Hypertension, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA.
出版信息
Cardiorenal Med. 2025;15(1):510-525. doi: 10.1159/000546201. Epub 2025 May 24.
BACKGROUND
Cardiopulmonary exercise testing (CPET) is an emerging tool in nephrology that has garnered significant interest among clinicians and investigators.
SUMMARY
CPET technology enables the user to accurately assess cardiovascular functional capacity using an integrative approach, to identify multi-organ reserve capacities and interrogate pathophysiological mechanisms underpinning impaired exercise tolerance in patients with chronic kidney disease (CKD). These capabilities provide rationale for accumulating studies exploring the use of this existing technology for new applications in nephrology and to solve current clinical practice barriers. Examples of current clinical interest areas include its potential to help transform diagnostic approaches to cardiovascular complications in patients with CKD, to offer superior cardiovascular risk stratification and to provide a solution to current limitations of traditional resting endpoints in cardiorenal clinical trials.
KEY MESSAGES
This article reviews the foundational principles, methodologic, and operational implementation of CPET in patients with CKD and those on dialysis.
背景
心肺运动试验（CPET）是肾脏病学中一种新兴的工具，已引起临床医生和研究人员的极大兴趣。
总结
CPET技术使用户能够采用综合方法准确评估心血管功能能力，识别多器官储备能力，并探究慢性肾脏病（CKD）患者运动耐量受损背后的病理生理机制。这些能力为越来越多探索将这项现有技术用于肾脏病学新应用及解决当前临床实践障碍的研究提供了理论依据。当前临床关注领域的例子包括其有助于改变CKD患者心血管并发症诊断方法的潜力、提供更优的心血管风险分层以及解决心肾临床试验中传统静息终点当前局限性的潜力。
关键信息
本文回顾了CPET在CKD患者和透析患者中的基本原则、方法学及操作实施。
Zotero 插件