Department of Obstetrics & Gynaecology, GROW School of Oncology and Developmental Biology, Maastricht University Medical Centre (MUMC+), Maastricht, the Netherlands.
Department of Clinical Epidemiology and Medical Technology Assessment (KEMTA), Maastricht University Medical Centre, Maastricht, the Netherlands.
Early Hum Dev. 2020 Dec;151:105199. doi: 10.1016/j.earlhumdev.2020.105199. Epub 2020 Sep 23.
Even though a lot of research has been done on postnatal growth and the occurrence of catch-up growth in small-for-gestational age (SGA) neonates, this phenomenon has not been studied well in appropriate-for-gestational age (AGA) neonates. Postnatal catch-up growth may also occur in AGA neonates indicating a compensatory mechanism for undiagnosed intrauterine growth restriction, especially in AGA neonates with reduced fetal growth velocity.
To describe postnatal growth during the first 5 years of life in SGA and AGA neonates and evaluating the role of fetal growth velocity in catch-up growth.
Retrospective study in a Dutch tertiary hospital.
740 singleton neonates, without congenital anomalies, with ultrasound fetal growth data from 20 weeks and 32 weeks of pregnancy.
Postnatal growth measurements of height (cm) and weight (kg) from birth until five years of age. Postnatal catch-up growth defined as difference (delta) in both height and weight between 4 weeks and 3 years of age.
SGA neonates had a significantly lower height and weight compared to the AGA group for all available measurement moments till 3 years. The catch-up growth between the SGA and AGA groups from 4 weeks up to 3 years after birth was not different between the two groups. However, neonates with reduced fetal growth velocity had a significantly higher risk for catch-up growth in height during the first 3 years after birth. This suggests a role for fetal growth velocity measurement in predicting fetal and subsequent postnatal growth potential.
尽管已经有很多关于小胎龄儿（SGA）出生后生长和追赶生长的研究，但对于适于胎龄儿（AGA）新生儿，这一现象尚未得到很好的研究。追赶生长也可能发生在 AGA 新生儿中，表明存在一种未诊断的宫内生长受限的代偿机制，尤其是在胎儿生长速度降低的 AGA 新生儿中。
描述 SGA 和 AGA 新生儿在出生后 5 年内的生长情况，并评估胎儿生长速度在追赶生长中的作用。
荷兰一家三级医院的回顾性研究。
740 名无先天畸形的单胎新生儿，有 20 周和 32 周妊娠的超声胎儿生长数据。
从出生到 5 岁时的身高（cm）和体重（kg）的生长测量值。追赶生长定义为出生后 4 周到 3 岁之间身高和体重的差异（delta）。
SGA 新生儿在所有可测量的时间点的身高和体重均明显低于 AGA 组。从出生后 4 周到 3 岁，SGA 和 AGA 两组之间的追赶生长没有差异。然而，胎儿生长速度降低的新生儿在出生后 3 年内身高追赶生长的风险显著增加。这表明胎儿生长速度测量在预测胎儿和随后的出生后生长潜力方面具有一定作用。
