Gorwill R H, Steele H D
Biol Neonate. 1985;48(2):110-3. doi: 10.1159/000242161.
Vaginal epithelial differentiation (VED) in the mouse and the human is the replacement of columnar by squamous epithelium in the vagina. This occurs in humans in late first and second trimesters of pregnancy and in mice after birth. In both diethylstilbestrol (DES) exposure during the process is associated with persistence of columnar epithelium and later reproductive tract tumor. Cardiac glycosides are estrogenic in both species. The concern: could cardiac glycosides produce similar effects to those seen after DES? Digitoxin was administered to Balb/c neonates at increasing doses. VED occurred by 10 days in three low-dose groups. Cardiotoxic mortality precluded study at higher doses. Therefore digitoxin did not affect VED.
小鼠和人类的阴道上皮分化（VED）是指阴道中柱状上皮被鳞状上皮取代的过程。这一过程在人类妊娠的孕晚期和孕中期出现，在小鼠出生后发生。在这两个物种中，在此过程中接触己烯雌酚（DES）均与柱状上皮的持续存在以及随后的生殖道肿瘤有关。强心苷在这两个物种中都具有雌激素样作用。问题是：强心苷是否会产生与DES类似的作用？将地高辛以递增剂量给予Balb/c新生小鼠。三个低剂量组在10天时出现了阴道上皮分化。更高剂量下由于心脏毒性导致的死亡使研究无法进行。因此，地高辛不影响阴道上皮分化。
