Gorwill R H, Steele H D, Sarda I R
Am J Obstet Gynecol. 1982 Nov 1;144(5):529-32. doi: 10.1016/0002-9378(82)90221-6.
Physiologically, the epithelium of the mouse vagina undergoes conversion during early postnatal life from columnar to stratified squamous. A similar process in the human occurs in the late first and early second trimesters of pregnancy. The mouse vagina has been identified as a good developmental model of the human. Previous work in the mouse has shown that this process is affected by neonatal administration of diethylstilbestrol. We have administered diethylstilbestrol and clomiphene citrate to parallel groups of BALB/c neonatal mice. They were followed up to 24 weeks. In both groups, persistent columnar or heterotopic columnar epithelium, not seen in the control mice, was identified and associated with adenosis. This effect of diethylstilbestrol and clomiphene citrate appears to be similar to the biologic response to transplacental diethylstilbestrol in the human. After transplacental diethylstilbestrol, malignant vaginal tumors rarely develop. If clomiphene citrate, given to the human prior to pregnancy to induce ovulation or by inadvertence during pregnancy, were to circulate into the critical time of vaginal differentiation, a similar biologic potential may exist. The first situation seems to be unlikely. The second is of more concern.
在生理上，小鼠阴道上皮在出生后早期会从柱状转变为复层鳞状。人类在妊娠的第一个月末和第二个月初也会发生类似过程。小鼠阴道已被确定为人类良好的发育模型。此前在小鼠身上的研究表明，这一过程会受到新生小鼠注射己烯雌酚的影响。我们给平行分组的BALB/c新生小鼠注射了己烯雌酚和枸橼酸氯米芬。对它们进行了长达24周的随访。在两组中，均发现了对照小鼠中未出现的持续性柱状或异位柱状上皮，并与腺病相关。己烯雌酚和枸橼酸氯米芬的这种作用似乎与人类经胎盘接触己烯雌酚后的生物学反应相似。接触经胎盘己烯雌酚后，很少发生阴道恶性肿瘤。如果在怀孕前给人类使用枸橼酸氯米芬以诱导排卵，或在怀孕期间意外使用，而其在阴道分化的关键时期进入循环，可能会存在类似的生物学潜能。第一种情况似乎不太可能。第二种情况更令人担忧。
