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中式香肠在体内模拟高热量诱导的肥胖，确定白藜芦醇丁酸酯单体衍生物对减肥和代谢综合征的潜在益处。

Chinese Sausage Simulates High Calorie-Induced Obesity In Vivo, Identifying the Potential Benefits of Weight Loss and Metabolic Syndrome of Resveratrol Butyrate Monomer Derivatives.

作者信息

Huang Ping-Hsiu, Chen Yu-Wei, Shie Cheng-Kai, Chen Shin-Yu, Lee Bao-Hong, Yin Li-Jung, Hou Chih-Yao, Shih Ming-Kuei

机构信息

School of Food, Jiangsu Food and Pharmaceutical Science College, No. 4, Meicheng Road, Higher Education Park, Huai'an, Jiangsu 223003, China.

Department of Food Science and Biotechnology, National Chung Hsing University, Taichung 40227, Taiwan.

出版信息

J Nutr Metab. 2025 May 16;2025:8414627. doi: 10.1155/jnme/8414627. eCollection 2025.

DOI:10.1155/jnme/8414627
PMID:40415762
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12101907/
Abstract

This study examined the health benefits of 3-O-butanoylresveratrol (ED4), a monoester derivative of resveratrol butyrate esters. Using a high-calorie diet model simulation with Chinese sausage, ED4 was tested against changes in physiological indices like body weight (BW), body fat, blood pressure, and SCFA levels (stools and serum) in rats. This study found that the obesity-inducing model utilizing sausage as a high-calorie diet worked, and that supplementing rats with ED4 (20 mg/kg BW/day) for 5 weeks inhibited BW increase and body fat buildup. Blood lipid and SCFA dysregulation improved significantly. In addition, ED4 effectively increased PPAR-γ and decreased SREBP-1C mRNA expression, preventing fat accumulation and overproduction. A novel food-driven relationship between gut microbiota and adipose was found, promoting health. Our findings showed that ED4 supplementation exacerbated metabolic abnormalities caused by high-calorie diets and reduced body fat. Notably, these metabolic benefits were enhanced through the involvement of intestinal microbiota.

摘要

本研究考察了白藜芦醇丁酸酯的单酯衍生物3 - O - 丁酰基白藜芦醇（ED4）对健康的益处。使用中式香肠进行高热量饮食模型模拟，针对大鼠的体重（BW）、体脂、血压和短链脂肪酸水平（粪便和血清）等生理指标的变化对ED4进行了测试。本研究发现，以香肠作为高热量饮食的肥胖诱导模型有效，并且给大鼠补充ED4（20毫克/千克体重/天）5周可抑制体重增加和体脂堆积。血脂和短链脂肪酸失调得到显著改善。此外，ED4有效增加了PPAR - γ并降低了SREBP - 1C mRNA表达，防止脂肪堆积和过量产生。发现了肠道微生物群与脂肪之间一种新的食物驱动关系，促进了健康。我们的研究结果表明，补充ED4加剧了高热量饮食引起的代谢异常并减少了体脂。值得注意的是，这些代谢益处通过肠道微生物群的参与而增强。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/9815eee9bd0a/JNME2025-8414627.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/d14ba580f20c/JNME2025-8414627.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/be421cb77fa4/JNME2025-8414627.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/99d69665f810/JNME2025-8414627.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/a7747dc5dc31/JNME2025-8414627.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/9815eee9bd0a/JNME2025-8414627.005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/d14ba580f20c/JNME2025-8414627.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/be421cb77fa4/JNME2025-8414627.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/99d69665f810/JNME2025-8414627.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/a7747dc5dc31/JNME2025-8414627.004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/be35/12101907/9815eee9bd0a/JNME2025-8414627.005.jpg

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