Teka Tesfay Berhe, Legese Haftom, Shishay Tsige, Mengesha Meresa Berwo, Gebremedhin Haftay
Department of Reproductive and family Health, College of Medicine and Health Science, Adigrat University, Adigrat, Ethiopia.
Department of Medical Laboratory, College of Medicine and Health Science, Adigrat University, Adigrat 0344452115, Ethiopia.
Ther Adv Vaccines Immunother. 2025 May 24;13:25151355251340205. doi: 10.1177/25151355251340205. eCollection 2025.
Human papillomavirus (HPV) continues to pose a significant threat to public health, serving as the primary cause of cervical cancer. To address this issue, a vaccine has been developed to decrease the incidence of cervical cancer. However, the practice and its associated factors with the uptake of the vaccine have not been well studied in this particular region. Consequently, this study aims to evaluate the practice of HPV vaccination and its associated factors among female adolescent students in the Eastern Zone of Tigray, North Ethiopia, 2024.
A cross-sectional study design was conducted from September 2023 to January 2024 at primary schools of the Eastern Zone, Tigray, Ethiopia. Data related to HPV vaccination practice and its associated factors were collected from 634 female adolescent primary school students. The collected data were checked for completeness daily, coded, entered, and cleaned using Epinfo version 7.2.3 then exported and analyzed using SPSS version 24. Bivariate and multivariate logistic regression analyses were used to assess the association between dependent and independent variables. The corresponding variables with a -value ( < 0.05) with a 95% confidence interval were considered statistically significant.
Among the 634 participants, 61.7% received the quadrivalent Gardasil HPV vaccine. Of these, 52.1% (330/634) demonstrated good knowledge, with an adjusted odds ratio (AOR) of 1.931 (95% confidence interval (CI), 1.364-2.735) and a -value < 0.000. Moreover, participants who had a positive attitude toward HPV vaccination, with (AOR = 1.529, 95% CI = 1.049-2.230; -value < 0.027) and participants who expressed their agreement for taking the HPV vaccine (AOR = 1.816, 95% CI = 1.046-3.152; -value < 0.034) were factors associated with female adolescent students' practice of the HPV vaccination.
The results indicated that the majority of study participants received one dose of the HPV vaccine. The study further reveals several factors associated with HPV vaccination among female adolescent students, including a positive attitude toward the vaccine and good knowledge about its benefits. Health authorities are recommended to promote the HPV vaccine through mass media in schools, religious institutions, and healthcare facilities to increase practice among adolescent females.
人乳头瘤病毒（HPV）持续对公众健康构成重大威胁，是宫颈癌的主要病因。为解决这一问题，已研发出一种疫苗以降低宫颈癌的发病率。然而，在这一特定地区，该疫苗的接种情况及其相关因素尚未得到充分研究。因此，本研究旨在评估2024年埃塞俄比亚北部提格雷东部地区女性青少年学生的HPV疫苗接种情况及其相关因素。
2023年9月至2024年1月在埃塞俄比亚提格雷东部地区的小学开展了一项横断面研究设计。从634名女性青少年小学生中收集了与HPV疫苗接种情况及其相关因素的数据。每天检查所收集数据的完整性，使用Epinfo 7.2.3版本进行编码、录入和清理，然后导出并使用SPSS 24版本进行分析。采用双变量和多变量逻辑回归分析来评估因变量和自变量之间的关联。P值（<0.05）且95%置信区间的相应变量被认为具有统计学意义。
在634名参与者中，61.7%接种了四价加德西HPV疫苗。其中，52.1%（330/634）具备良好的知识，调整后的优势比（AOR）为1.931（95%置信区间（CI），1.364 - 2.735），P值<0.000。此外，对HPV疫苗接种持积极态度的参与者（AOR = 1.529，95% CI = 1.049 - 2.230；P值<0.027）以及表示同意接种HPV疫苗的参与者（AOR = 1.816，95% CI = 1.046 - 3.152；P值<0.034）是与女性青少年学生HPV疫苗接种情况相关的因素。
结果表明，大多数研究参与者接种了一剂HPV疫苗。该研究进一步揭示了与女性青少年学生HPV疫苗接种相关的几个因素，包括对疫苗的积极态度以及对其益处的良好认知。建议卫生当局通过学校、宗教机构和医疗机构的大众媒体来推广HPV疫苗，以提高青少年女性的接种率。
