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利用内生菌ZMS36生物合成双金属银-氧化铜纳米颗粒及其生物医学应用。

Biosynthesis of bimetallic silver-copper oxide nanoparticles using endophytic ZMS36 and their biomedical applications.

作者信息

Chen Zhijiang, Lv Tianyu, Zhang Yuxing, Kong Weitao, Li Xixian, Xie Siyun, Li Jiaqi, Long Yu, Chen Liqing, Liu Jiarong, Li Zhiqi, Zeng Xingda, Deng Zujun

机构信息

Guangdong Provincial Key Laboratory of Pharmaceutical Bioactive Substances, School of Basic Medical Sciences, Guangdong Pharmaceutical University, Guangzhou, China.

出版信息

Front Microbiol. 2025 May 9;16:1581486. doi: 10.3389/fmicb.2025.1581486. eCollection 2025.

DOI:10.3389/fmicb.2025.1581486
PMID:40415926
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12098627/
Abstract

Bimetallic nanoparticles (BMNPs) have garnered significant interest owing to their exceptional physicochemical properties. However, there have been few reports of the biosynthesis of BMNPs using endophytic fungi from medicinal plants. The objectives of this study were to isolate endophytic fungi from medicinal plant to synthesize bimetallic Ag-CuO nanoparticles (Ag-CuO NPs), characterize the biosynthesized Ag-CuO NPs and assess their bioactivity and biosafety. The endophytic fungus ZMS36 capable of biosynthesizing Ag-CuO NPs was isolated from medicinal plant and identified as . The Ag-CuO NPs were biosynthesized using endophytic ZMS36 and characterized by UV-visible, SEM, TEM, EDS, XRD, and FTIR. The Ag-CuO NPs exhibited good antibacterial activity against , and . They also significantly inhibited the growth of MRSA and the expression of gene, especially in conjunction with vancomycin, the preferred antibiotic for clinical treatment of MRSA infections. The Ag-CuO NPs showed promising anticancer activity in antiproliferative assays on the tumor cell lines HeLa, PDSF, and A549. Furthermore, the Ag-CuO NPs inhibited the migration of HeLa cells as well as angiogenesis in chicken embryos, helping to inhibit tumor metastasis. Interestingly, the Ag-CuO NPs showed low cytotoxicity, indicating good biocompatibility. This study revealed the potential of endophytic fungi from medicinal plants to synthesize BMNPs and highlighted biosynthetic Ag-CuO NPs as promising novel antibacterial and anticancer nanodrugs for future biomedical applications.

摘要

双金属纳米颗粒（BMNPs）因其优异的物理化学性质而备受关注。然而，利用药用植物内生真菌生物合成BMNPs的报道却很少。本研究的目的是从药用植物中分离内生真菌，以合成双金属Ag-CuO纳米颗粒（Ag-CuO NPs），对生物合成的Ag-CuO NPs进行表征，并评估其生物活性和生物安全性。从药用植物中分离出能够生物合成Ag-CuO NPs的内生真菌ZMS36，并将其鉴定为 。利用内生真菌ZMS36生物合成Ag-CuO NPs，并通过紫外可见光谱、扫描电子显微镜、透射电子显微镜、能谱分析、X射线衍射和傅里叶变换红外光谱对其进行表征。Ag-CuO NPs对 、 和 表现出良好的抗菌活性。它们还显著抑制了耐甲氧西林金黄色葡萄球菌（MRSA）的生长和 基因的表达，尤其是与万古霉素联合使用时，万古霉素是临床治疗MRSA感染的首选抗生素。在对肿瘤细胞系HeLa、PDSF和A549的抗增殖试验中，Ag-CuO NPs显示出有前景的抗癌活性。此外，Ag-CuO NPs抑制了HeLa细胞的迁移以及鸡胚中的血管生成，有助于抑制肿瘤转移。有趣的是，Ag-CuO NPs显示出低细胞毒性，表明其具有良好的生物相容性。本研究揭示了药用植物内生真菌合成BMNPs的潜力，并强调生物合成的Ag-CuO NPs作为未来生物医学应用中有望的新型抗菌和抗癌纳米药物的潜力。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/753b/12098627/2173c015c79b/fmicb-16-1581486-g0014.jpg
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