Aziz Maryam, Malik Laiba Urooj, Javed Erum, Sami Syeda Zuha, Maaz Muhammad, Khan Muhammad Arham, Farmaan Muhammad, Farooq Omer, Iqbal Umer, Kumar Aashish, Arsal Syed Ali, Amin Shafin Bin, Okon Inibehe Ime
Department of Medicine Dow University of Health Sciences Karachi Pakistan.
Department of Medicine Shaheed Mohtarma Benazir Bhutto Medical College Karachi Pakistan.
Health Sci Rep. 2025 May 22;8(5):e70849. doi: 10.1002/hsr2.70849. eCollection 2025 May.
Loperamide and racecadotril are two antidiarrheal medications with different mechanisms of action that are highly important for the treatment of diarrhea as a result of infectious pathology. Acute infectious diarrhea has a profound impact on our surroundings because of its detrimental effects on individual health. Medication such as racecadotril, among various other drug classes, plays a pivotal role in treating these diseases via the management of symptoms through its antisecretory, proabsorptive effects on the intestinal tract. The main objective of this analysis was to evaluate and contrast the usefulness and safety profiles of these drugs by combining information from randomized controlled trials and highlighting important side effects reported, such as constipation and stomach discomfort.
A total of 117 records were found after a thorough literature search was carried out across several databases, including PubMed, Google Scholar, and the Cochrane Library. The Cochrane Collaboration technique was utilized to evaluate the potential for bias. RevMan 5.2 data analysis was performed via a random effects model. The results are displayed as the mean difference (MD) with 95% CI for continuous data and relative risk (RR) with 95% confidence intervals (CIs) for dichotomous data. Statistical significance was established at < 0.05.
Compared with loperamide, racecadotril significantly improved the clinical response (relative risk [RR] and 95% confidence interval [CI]). Additionally, the analysis of secondary outcomes revealed varying effects on abdominal pain, constipation, and abdominal enlargement, with moderate heterogeneity observed (² = 56%).
Compared with loperamide, racecadotril is a better therapeutic option for adult diarrhea caused by infection.
洛哌丁胺和消旋卡多曲是两种作用机制不同的止泻药物，对治疗感染性病理导致的腹泻非常重要。急性感染性腹泻因其对个体健康的有害影响，对我们的周围环境有深远影响。消旋卡多曲等药物在各类药物中，通过对肠道的抗分泌、促吸收作用来管理症状，在治疗这些疾病中发挥着关键作用。本分析的主要目的是通过整合随机对照试验的信息，评估和对比这些药物的有效性和安全性概况，并突出报道的重要副作用，如便秘和胃部不适。
在全面检索包括PubMed、谷歌学术和Cochrane图书馆在内的多个数据库后，共找到117条记录。采用Cochrane协作技术评估偏倚可能性。通过随机效应模型进行RevMan 5.2数据分析。连续数据的结果以均数差（MD）及95%置信区间（CI）表示，二分数据的结果以相对危险度（RR）及95%置信区间（CI）表示。设定P < 0.05为具有统计学意义。
与洛哌丁胺相比，消旋卡多曲显著改善了临床反应（相对危险度[RR]及95%置信区间[CI]）。此外，次要结局分析显示对腹痛、便秘和腹部膨隆有不同影响，观察到中度异质性（I² = ５6%）。
与洛哌丁胺相比，消旋卡多曲是治疗成人感染性腹泻的更好治疗选择。
