Smirnova O V, Vishniakova T G, Rozen V B
Biull Eksp Biol Med. 1985 Sep;100(9):342-5.
The effects of androgens (A), estrogens (E) and hypophysectomy on the content of an unusual rat liver estrogen-binding protein (UEBP) were studied by the differential quantitative method of the UEBP content measurement. The UEBP content was shown to increase during maturation of male rats. After A injections the UEBP content was high only in the liver of prepubertal but not of mature or immature males. Castration or hypophysectomy of mature males equally caused a decrease in the UEBP content in mature males whereas subsequent administration of A made it completely return to normal. Hypophysectomy of castrated males did not alter the UEBP content. A single injection of E provoked an appreciable reduction in the UEBP level after several days. Administration of A interfered with the inhibitory action of E after simultaneous injection of A and E and recovered the E-induced lowering of the UEBP content upon administration of A following E. Hypophysectomy of castrated males did not affect significantly the UEBP level. The UEBP content was insensitive to the direct action of pituitary factors. The pituitary is necessary for the realization of the effects of E alone but not A. It is suggested that the regulatory role of A consists in the maintenance of the constant optimal UEBP level in rat liver.
采用差异定量法测定大鼠肝脏中一种特殊雌激素结合蛋白（UEBP）的含量，研究雄激素（A）、雌激素（E）及垂体切除对其含量的影响。结果显示，雄性大鼠成熟过程中UEBP含量增加。注射A后，仅青春期前雄性大鼠肝脏中的UEBP含量升高，成熟或未成熟雄性大鼠肝脏中的UEBP含量未升高。成熟雄性大鼠去势或垂体切除均导致UEBP含量降低，而随后给予A可使其完全恢复正常。去势雄性大鼠垂体切除未改变UEBP含量。单次注射E数天后，UEBP水平显著降低。同时注射A和E时，A可干扰E的抑制作用，E注射后再给予A可恢复E诱导的UEBP含量降低。去势雄性大鼠垂体切除对UEBP水平无显著影响。UEBP含量对垂体因子的直接作用不敏感。垂体对于单独发挥E的作用是必需的，但对A则不是。提示A的调节作用在于维持大鼠肝脏中UEBP水平的恒定最优值。
