Singh Navneet, Goyal Rohit, Talreja Lakhan, Sheshamani Niyutna, Mugalikar Aditi, Dixit Sagar R, Kaushik Rashi
Department of Oral and Maxillofacial Surgery, Maharaja Ganga Singh Dental College and Research Centre, Sri Ganganagar, IND.
Department of Oral and Maxillofacial Surgery, Derma Dental, Navi Mumbai, IND.
Cureus. 2025 Apr 24;17(4):e82891. doi: 10.7759/cureus.82891. eCollection 2025 Apr.
Healing of extraction sockets is a critical factor in oral and maxillofacial surgery, particularly when preserving alveolar bone and periodontal stability is essential. Platelet-rich plasma (PRP), an autologous concentrate of growth factors, has gained attention for its potential to enhance bone regeneration and soft-tissue healing. This study aimed to evaluate the clinical and radiographic outcomes of PRP application in extraction sockets after impacted mandibular third molar surgery.
Forty patients who underwent impacted mandibular third molar extraction were divided into two groups according to clinical decision-making in conjunction with patient preference: the PRP group, in which PRP was applied in the extraction socket, and the non-PRP group, which received standard post-extraction care. Clinical parameters, including probing depth and wound closure, and radiographic assessments of alveolar bone level and bone density were recorded at baseline, one month, three months, and six months postoperatively.
The application of PRP resulted in significant improvements in alveolar bone preservation and periodontal health, with a notable reduction in probing depth compared to the non-PRP group. Although PRP did not show a significant difference in bone density between the groups, a sustained increase over time suggested a positive effect on bone remodeling. PRP also accelerated wound healing, with initial dehiscence observed, but improved closure by day seven, indicating a biphasic influence on tissue repair.
PRP demonstrated potential benefits in enhancing soft and hard tissue healing after mandibular third molar extraction. Its ability to promote periodontal stability and wound closure suggests its clinical utility for oral surgical procedures. However, larger randomized controlled trials with extended follow-up are needed to establish standardized protocols and confirm their long-term efficacy.
拔牙创口的愈合是口腔颌面外科的一个关键因素，尤其是在保留牙槽骨和牙周稳定性至关重要的情况下。富血小板血浆（PRP）是一种生长因子的自体浓缩物，因其增强骨再生和软组织愈合的潜力而受到关注。本研究旨在评估PRP在下颌阻生第三磨牙拔除术后应用于拔牙创的临床和影像学效果。
40例接受下颌阻生第三磨牙拔除术的患者，根据临床决策并结合患者偏好分为两组：PRP组，在拔牙创中应用PRP；非PRP组，接受标准的拔牙后护理。在术后基线、1个月、3个月和6个月记录临床参数，包括探诊深度和创口闭合情况，以及牙槽骨水平和骨密度的影像学评估。
与非PRP组相比，PRP的应用在牙槽骨保存和牙周健康方面有显著改善，探诊深度明显降低。虽然两组之间PRP在骨密度方面没有显示出显著差异，但随着时间的推移持续增加表明对骨重塑有积极影响。PRP还加速了创口愈合，最初观察到有裂开，但在第7天创口闭合情况改善，表明对组织修复有双相影响。
PRP在下颌第三磨牙拔除术后增强软硬组织愈合方面显示出潜在益处。其促进牙周稳定性和创口闭合的能力表明其在口腔外科手术中的临床实用性。然而，需要更大规模的随机对照试验并延长随访时间，以建立标准化方案并确认其长期疗效。
