Department of Cardiology, Kahramanmaraş Sütçü Imam University Faculty of Medicine, Kahramanmaraş, Turkey.
Department of Biochemistry, Kahramanmaraş Sütçü Imam University Faculty of Medicine, Kahramanmaraş, Turkey.
Scand J Clin Lab Invest. 2020 Jul;80(4):277-281. doi: 10.1080/00365513.2020.1728786. Epub 2020 Feb 20.
Environmental, genetic, oxidative and biochemical factors play an important role in the atherosclerotic process. We investigated the association of serum fibroblast growth factor (FGF-23), klotho, fetuin-A, osteoprotegerin (OPG), osteopontin (OPN) and high-sensitive-CRP (Hs-CRP) markers with coronary artery disease and whether one was superior to others or not. A study group of 52 patients with coronary artery disease (CAD) and a control group of 30 patients with angiographically normal epicardial coronary arteries were included in the study. Serum FGF-23, klotho, fetuin-A, OPN, OPG and Hs-CRP marker levels were studied. Patients with CAD were classified in two groups as low (SYNTAX ≤22, = 29) and moderate-high (SYNTAX ≥ 23, = 23) according to anatomic SYNTAX score. FGF-23 ( = .033), klotho ( < .001), fetuin-A ( = .005) and OPG ( = .001) serum marker levels were significantly lower in CAD patients than the control group. Serum levels of FGF-23 ( = .012), klotho ( = .001), fetuin-A ( = .015) and OPG ( = 0.002) were significantly different between SYNTAX tertiles and control group. Klotho ( = .025, odd ratio (OR) = 0.542, 95% confidence interval (CI): 0.317-0.926) and HT ( = .004, OR = 34.598, 95%CI:1.054-1135.657) were the independent predictors of CAD presence. Serum klotho levels of 91.48 pmol/L predicts the presence of CAD with 60% sensitivity and 96.55% specificity ( < .001, area under curve = 0.864, 95% CI = 0.768, 0.931). We found that serum klotho level is an independent predictor of presence, extent and severity of CAD.
环境、遗传、氧化和生化因素在动脉粥样硬化过程中起着重要作用。我们研究了血清成纤维细胞生长因子 (FGF-23)、klotho、胎球蛋白-A、骨保护素 (OPG)、骨桥蛋白 (OPN) 和高敏-C 反应蛋白 (Hs-CRP) 标志物与冠状动脉疾病的相关性，以及它们是否存在优势。研究纳入了 52 例冠状动脉疾病 (CAD) 患者的研究组和 30 例冠状动脉造影正常的患者对照组。研究了血清 FGF-23、klotho、胎球蛋白-A、OPN、OPG 和 Hs-CRP 标志物水平。根据解剖学 SYNTAX 评分，将 CAD 患者分为两组：低 (SYNTAX≤22， = 29) 和中高 (SYNTAX≥23， = 23)。与对照组相比，CAD 患者的 FGF-23 ( = .033)、klotho ( < .001)、胎球蛋白-A ( = .005) 和 OPG ( = .001) 血清标志物水平显著降低。血清 FGF-23 ( = .012)、klotho ( = .001)、胎球蛋白-A ( = .015) 和 OPG ( = 0.002) 水平在 SYNTAX 三分位数与对照组之间存在显著差异。klotho ( = .025，比值比 (OR) = 0.542，95%置信区间 (CI)：0.317-0.926) 和 HT ( = .004，OR = 34.598，95%CI：1.054-1135.657) 是 CAD 存在的独立预测因子。血清 klotho 水平为 91.48 pmol/L 时，预测 CAD 的敏感性为 60%，特异性为 96.55% ( < .001，曲线下面积 = 0.864，95%CI：0.768,0.931)。我们发现血清 klotho 水平是 CAD 存在、程度和严重程度的独立预测因子。
