The First Hospital of Nanping City, No. 317 Zhongshan Road, Nanping City, Fujian Province, PR China.
Medicine (Baltimore). 2021 Oct 29;100(43):e27481. doi: 10.1097/MD.0000000000027481.
Fetuin-A plays an important role in antivascular calcification and inflammatory response, it is necessary to explore the relationship between fetuin-A and coronary atherosclerotic heart disease (CHD) and CHD-related risk factors.A total of 92 patients with CHD as the research group, and 60 healthy persons as the control group were enrolled from May 2019 to May 2020. Fetuin-A levels were determined by enzyme-linked immunosorbent assay, and the characteristics and clinical data were collected and compared. Logistic regression was used to analyze the factors influencing CHD.The age, proportion of males, patients with hypertension and diabetes, as well as fetuin-A level in the research group were significantly higher than those in the control group, but the high-density lipoprotein cholesterol level was significantly lower than that in the control group (P < .05). Logistic regression analysis and correction showed that gender, age, blood pressure, and diabetes were related to the onset of CHD, and there was a significant correlation between the level of fetuin-A and age (P < .05).Serum fetuin-A was related to the onset risk of CHD, and showed a significant correlation with age.
胎球蛋白-A 在抗血管钙化和炎症反应中发挥重要作用，有必要探讨胎球蛋白-A 与冠状动脉粥样硬化性心脏病（CHD）及 CHD 相关危险因素的关系。选取 2019 年 5 月至 2020 年 5 月期间收治的 92 例 CHD 患者作为研究组，选取同期体检的 60 例健康者作为对照组。采用酶联免疫吸附法测定胎球蛋白-A 水平，收集并比较两组的特征及临床资料。采用 logistic 回归分析影响 CHD 的因素。结果研究组患者的年龄、男性比例、高血压和糖尿病患者比例及胎球蛋白-A 水平均明显高于对照组，而高密度脂蛋白胆固醇水平明显低于对照组（P<0.05）。logistic 回归分析及校正显示，性别、年龄、血压和糖尿病与 CHD 的发病有关，且胎球蛋白-A 水平与年龄呈显著相关（P<0.05）。血清胎球蛋白-A 与 CHD 的发病风险相关，且与年龄呈显著正相关。
