粗制软毛曼陀罗提取物对大鼠离体子宫缓激肽作用的选择性拮抗作用。
The selective antagonism of bradykinin action on rat isolated uterus by crude Mandevilla velutina extract.
作者信息
Calixto J B, Nicolau M, Yunes R A
出版信息
Br J Pharmacol. 1985 Aug;85(4):729-31. doi: 10.1111/j.1476-5381.1985.tb11069.x.
Abstract
A crude aqueous alcoholic extract of Mandevilla velutina (Apocynaceae) rhizomes produced a concentration-dependent displacement to the right of the concentration-response curve to bradykinin (Bk) in the isolated uterus of the rat. Schild analysis of the data revealed a linear relationship (r = 0.99) and yielded a pA2 value of 3.3 + 0.08 (- log g ml-1) but the slope differed significantly from unity. The anti-Bk action was of rapid onset and was reversible upon washout. Contractions induced by acetylcholine, oxytocin, angiotensin II and BaCl2 were unaffected by the extract. This represents the first report of a selective Bk antagonist of plant origin. The isolation of the active principle(s) may result in a useful pharmacological tool for elucidating the physiological and physiopathological roles of endogenous Bk.
摘要
曼德维拉绒毛根（夹竹桃科）的粗制水醇提取物，在大鼠离体子宫中，使缓激肽（Bk）浓度-反应曲线向右产生浓度依赖性位移。对数据进行的Schild分析显示呈线性关系（r = 0.99），pA2值为3.3 + 0.08（-log g ml-1），但斜率与1有显著差异。抗Bk作用起效迅速，冲洗后可逆。乙酰胆碱、催产素、血管紧张素II和BaCl2诱导的收缩不受该提取物影响。这是关于植物来源的选择性Bk拮抗剂的首次报道。活性成分的分离可能会产生一种有用的药理学工具，用于阐明内源性Bk的生理和病理生理作用。
相似文献
1
The selective antagonism of bradykinin action on rat isolated uterus by crude Mandevilla velutina extract.粗制软毛曼陀罗提取物对大鼠离体子宫缓激肽作用的选择性拮抗作用。
Br J Pharmacol. 1985 Aug;85(4):729-31. doi: 10.1111/j.1476-5381.1985.tb11069.x.
2
Kinin antagonist activity of compounds from Mandevilla velutina in the rat isolated uterus.曼德维拉绒毛花中化合物对大鼠离体子宫的激肽拮抗剂活性。
Br J Pharmacol. 1987 May;91(1):199-204. doi: 10.1111/j.1476-5381.1987.tb08999.x.
3
The competitive antagonistic effect of compounds from Mandevilla velutina on kinin-induced contractions of rat uterus and guinea-pig ileum in vitro.软毛蔓长春花化合物对激肽诱导的大鼠子宫和豚鼠回肠体外收缩的竞争性拮抗作用。
Br J Pharmacol. 1988 Aug;94(4):1133-42. doi: 10.1111/j.1476-5381.1988.tb11631.x.
4
Antagonism of kinin-induced contraction of isolated rat uterus by the crude hydroalcoholic extract from Mandevilla illustris.
Gen Pharmacol. 1991;22(1):99-101. doi: 10.1016/0306-3623(91)90316-x.
5
Action of pregnane compounds from Mandevilla illustris against contractions induced by kinins and other oxytocics in the rat isolated uterus.
Gen Pharmacol. 1991;22(6):1071-5. doi: 10.1016/0306-3623(91)90579-u.
6
Effect of a crude extract of Mandevilla velutina on contractions induced by bradykinin and [des-Arg9]-bradykinin in isolated vessels of the rabbit.软毛曼德维拉粗提取物对兔离体血管中缓激肽和[去-精氨酸9]-缓激肽诱导的收缩的影响。
Br J Pharmacol. 1986 Aug;88(4):937-41. doi: 10.1111/j.1476-5381.1986.tb16269.x.
7
Demonstration of anti-bradykinin compounds in callus cultures of Mandevilla velutina.
Braz J Med Biol Res. 1989;22(10):1275-9.
8
Blockade of the bradykinin-evoked diphasic response of isolated rat duodenum by the crude extract of and compounds obtained from Mandevilla velutina.
Braz J Med Biol Res. 1988;21(5):1015-8.
9
Antagonistic effect of Mandevilla velutina extract on kinin-induced contractions of guinea-pig and cat ileum longitudinal smooth muscle.
Gen Pharmacol. 1988;19(4):595-9. doi: 10.1016/0306-3623(88)90170-x.
10
Blockade of kinin-induced responses of the guinea-pig isolated urinary bladder by the extract of Mandevilla velutina.
Gen Pharmacol. 1990;21(3):285-90. doi: 10.1016/0306-3623(90)90823-5.
引用本文的文献
1
Tissue, cell culture and micropropagation of Mandevilla velutina, a natural source of a bradykinin antagonist.马缨丹的组织、细胞培养和微繁殖，一种缓激肽拮抗剂的天然来源。
Plant Cell Rep. 1988 Dec;7(7):564-6. doi: 10.1007/BF00272758.
2
Effects of the compounds MV8608 and MV8612 obtained from Mandevilla velutina in the model of hemorrhagic cystitis induced by cyclophosphamide in rats.从马缨丹中提取的化合物 MV8608 和 MV8612 对环磷酰胺诱导的大鼠出血性膀胱炎模型的影响。
Naunyn Schmiedebergs Arch Pharmacol. 2010 Dec;382(5-6):399-407. doi: 10.1007/s00210-010-0555-0. Epub 2010 Sep 1.
3
Evidence for participation of B1 and B2 kinin receptors in formalin-induced nociceptive response in the mouse.B1和B2激肽受体参与小鼠福尔马林诱导的伤害性反应的证据。
Br J Pharmacol. 1993 Sep;110(1):193-8. doi: 10.1111/j.1476-5381.1993.tb13791.x.
4
Effect of a crude extract of Mandevilla velutina on contractions induced by bradykinin and [des-Arg9]-bradykinin in isolated vessels of the rabbit.软毛曼德维拉粗提取物对兔离体血管中缓激肽和[去-精氨酸9]-缓激肽诱导的收缩的影响。
Br J Pharmacol. 1986 Aug;88(4):937-41. doi: 10.1111/j.1476-5381.1986.tb16269.x.
5
Kinin antagonist activity of compounds from Mandevilla velutina in the rat isolated uterus.曼德维拉绒毛花中化合物对大鼠离体子宫的激肽拮抗剂活性。
Br J Pharmacol. 1987 May;91(1):199-204. doi: 10.1111/j.1476-5381.1987.tb08999.x.
6
The competitive antagonistic effect of compounds from Mandevilla velutina on kinin-induced contractions of rat uterus and guinea-pig ileum in vitro.软毛蔓长春花化合物对激肽诱导的大鼠子宫和豚鼠回肠体外收缩的竞争性拮抗作用。
Br J Pharmacol. 1988 Aug;94(4):1133-42. doi: 10.1111/j.1476-5381.1988.tb11631.x.
7
Pharmacological evaluation of rat paw oedema induced by Bothrops jararaca venom.矛头蝮蛇毒诱导的大鼠足爪水肿的药理学评价
Agents Actions. 1989 Mar;26(3-4):292-300. doi: 10.1007/BF01967293.
8
Inhibition of rat paw oedema and pleurisy by the extract from Mandevilla velutina.软叶文藤提取物对大鼠足爪水肿和胸膜炎的抑制作用
Agents Actions. 1991 Jul;33(3-4):272-8. doi: 10.1007/BF01986573.
本文引用的文献
1
A BRADYKININ-POTENTIATING FACTOR (BPF) PRESENT IN THE VENOM OF BOTHROPS JARARCA.存在于矛头蝮蛇毒液中的一种缓激肽增强因子（BPF）。
Br J Pharmacol Chemother. 1965 Feb;24(1):163-9. doi: 10.1111/j.1476-5381.1965.tb02091.x.
2
Some quantitative uses of drug antagonists.药物拮抗剂的一些定量应用。
Br J Pharmacol Chemother. 1959 Mar;14(1):48-58. doi: 10.1111/j.1476-5381.1959.tb00928.x.
3
Prostaglandins and the regulation of uterine blood flow in pregnancy.前列腺素与孕期子宫血流的调节
Nature. 1974 May 3;249(452):57-8. doi: 10.1038/249057a0.
4
Ketamine-inhibition of calcium-induced contractions in depolarized rat uterus: a comparison with other calcium antagonists.氯胺酮对去极化大鼠子宫中钙诱导收缩的抑制作用：与其他钙拮抗剂的比较。
Br J Pharmacol. 1985 May;85(1):189-95. doi: 10.1111/j.1476-5381.1985.tb08846.x.
Zotero 插件