Tiwari Bhaskar, Liermann Hanns-Peter, Parsons Simon, Giordano Nico
Centre for Science at Extreme Conditions and School of Chemistry, The University of Edinburgh EH9 3FJ Edinburgh, U.K.
Deutsches Elektronen-Synchrotron DESY, Notkestr. 85, 22607 Hamburg, Germany.
Cryst Growth Des. 2025 May 12;25(10):3537-3547. doi: 10.1021/acs.cgd.5c00372. eCollection 2025 May 21.
The effect of high pressure on ribavirin, a broad-spectrum antiviral consisting of ribofuranosyl triazole, and carboxamide moieties, has been studied up to ∼10 GPa. Three new high-pressure phases, designated , and , have been obtained by compression of the ambient-pressure form with structures refined up to 7.5 GPa. The new phases are formed at 5.3, 6.0, and 7.2 GPa, respectively, and crystallize in space group 222 with ' = 3, 1, and 1. They are distinguished by changes in the conformation of the ribofuranosyl moiety which impacts both the molecular geometry and the supramolecular structure.
已对高达约10吉帕斯卡压力下的利巴韦林（一种由呋喃核糖基三唑和羧酰胺部分组成的广谱抗病毒药物）的作用进行了研究。通过对常压下的 形式进行压缩，获得了三个新的高压相，分别命名为 、 和 ，其结构已精修至7.5吉帕斯卡。新相分别在5.3吉帕斯卡、6.0吉帕斯卡和7.2吉帕斯卡下形成，并在空间群222中结晶，其中 ' = 3、1和1。它们的区别在于呋喃核糖基部分构象的变化，这对分子几何形状和超分子结构都有影响。
