While the digitalization of healthcare and the advent of consumer-centered technologies have led to advancements in patient engagement, it is evident that certain, underprivileged segments of society might not be benefiting. The purpose of this review was to thus analyze the expanding data focusing on digital disparities in healthcare and was designed based on the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) statement. First, a literature search of original, peer-reviewed publications was undertaken to identify studies pertaining to disparities in the utilization of digital technologies in healthcare using a variety of customized retrieval terms. Articles published from January 2014 to January 2024 were included. Subsequently, a total of 247 peer-reviewed studies were identified which were used to construct a framework for interpretation. The core themes could broadly be categorized into digital health portals ( = 74), telemedicine ( = 57), healthcare wearables ( = 49), digital intervention tools ( = 35), and virtual education ( = 32). While the potential of digital health to fundamentally transform the nature of patient-centric care is increasingly being recognized, the growing "digital divide" between the "haves" and "have-nots" with respect to nearly every facet of technology implementation raises concern regarding the perpetuation of inequities across society.