Govorov Igor, Komlichenko Eduard, Ulrikh Elena, Dikareva Elena, Pervunina Tatiana, Vazhenina Oksana, Dzharbaeva Amina, Kalinina Olga, Zaikova Ekaterina, Razumova Zoia, Mints Miriam, Sitkin Stanislav
Almazov National Medical Research Centre, Saint-Petersburg, Russia.
Division of Obstetrics and Gynecology, Department of Women's and Children's Health, Karolinska Institutet, Stockholm, Sweden.
Front Med (Lausanne). 2025 May 9;12:1533344. doi: 10.3389/fmed.2025.1533344. eCollection 2025.
Endometrial cancer remains one of the most common malignancies in women, and its incidence is particularly increasing in developed countries. Despite the well-known promotive role of excessive exposure to estrogen, many other details of the pathogenesis of endometrial cancer remain unknown. Recent studies have elucidated the emerging role of the resident microbiota in the progression of various diseases, including cancer. Next-generation sequencing demonstrated that the uterine cavity, previously considered sterile, contains a composition-rich microbiota. In this work, we determined the differences in the composition of the intrauterine microbiota between patients with endometrial cancer and its precursor-endometrial hyperplasia.
子宫内膜癌仍然是女性中最常见的恶性肿瘤之一，并且在发达国家其发病率尤其呈上升趋势。尽管过度暴露于雌激素的促癌作用众所周知，但子宫内膜癌发病机制的许多其他细节仍不清楚。最近的研究阐明了常驻微生物群在包括癌症在内的各种疾病进展中的新作用。下一代测序表明，以前被认为无菌的子宫腔内含有丰富的微生物群。在这项研究中，我们确定了子宫内膜癌患者与其癌前病变——子宫内膜增生患者子宫内微生物群组成的差异。
