Fitzsimons R B, Wolfenden W H
Brain. 1985 Sep;108 ( Pt 3):555-77. doi: 10.1093/brain/108.3.555-a.
A family with hemiplegic migraine has been documented for a period of over forty years. From this study and the literature we conclude that (1) migraine is a cause of recurrent coma which may be associated with life-threatening cerebral hemisphere oedema; (2) hyperpyrexia with CSF pleocytosis occurs in hemiplegic migraine, which may thus simulate viral meningoencephalitis; and (3) cerebral angiography is hazardous in hemiplegic migraine and may exacerbate coma and cerebral oedema. In the family reported, cerebellar ataxia was present during recovery from attacks of hemiplegic migraine and affected patients ultimately suffered from persistent ataxia with radiological cerebellar atrophy. This syndrome thus constitutes a distinct form of late-onset autosomal dominant cerebellar ataxia and also of familial periodic ataxia. The status of 'cerebellar migraine' is reviewed.
一个患有偏瘫性偏头痛的家族已有四十多年的记录。通过这项研究和文献，我们得出以下结论：（1）偏头痛是反复昏迷的一个原因，可能与危及生命的大脑半球水肿有关；（2）偏瘫性偏头痛会出现高热伴脑脊液细胞增多，因此可能类似病毒性脑膜脑炎；（3）脑血管造影术在偏瘫性偏头痛中具有危险性，可能会加重昏迷和脑水肿。在报告的这个家族中，偏瘫性偏头痛发作恢复期间出现了小脑共济失调，受影响的患者最终患有持续性共济失调，并伴有影像学上的小脑萎缩。因此，这种综合征构成了一种独特的迟发性常染色体显性小脑共济失调形式，也是家族性周期性共济失调的一种形式。本文对“小脑性偏头痛”的状况进行了综述。
