[Suicidal ideation and behaviors: a transdiagnostic dimension for precision psychiatry].

Suicidal thoughts and behaviors represent a transdiagnostic dimension independent of traditional psychiatric diagnoses. This specificity is supported by genetic studies, biomarkers, and preclinical research on endophenotypes associated with suicidal behaviors, such as impulsivity, anhedonia, and hopelessness. Clear mechanisms involving inflammation, the stress response, the serotonergic system, and neuroplasticity are emerging. Specific treatments, such as lithium and ketamine, target these mechanisms. The French Minds cohort of the PEPR PROPSY will identify the biological signatures and trajectories of this dimension using comprehensive multimodal approaches.