Iftimovici Anton, Jardri Renaud, Lefebvre Aline, Mallet Jasmina, Lefrere Antoine
Université Paris Cité, Institut de psychiatrie et neurosciences de Paris (IPNP), Inserm U1266, GHU-Paris Psychiatrie et Neurosciences, Hôpital Sainte-Anne, Paris, France.
Université de Lille, Inserm U1172, Centre de recherche Lille neuroscience et cognition (LilNCog), Plateforme CURE, CHU de Lille, Hôpital Fontan, Lille, France.
Med Sci (Paris). 2025 May;41(5):451-459. doi: 10.1051/medsci/2025071. Epub 2025 May 26.
The neurodevelopmental dimension represents a major challenge for the future of precision psychiatry. It provides a transdiagnostic framework, that allows for the redefinition of psychiatric disorders beyond traditional diagnostic categories, such as autism spectrum disorders, attention-deficit/hyperactivity disorder, schizophrenia, and bipolar disorder. This model is based on the identification of deviations in brain developmental trajectories during critical periods of vulnerability. Using multimodal approaches that integrate clinical, biological, neuroimaging, and neurophysiological data, this framework aims to define an individualized neurodevelopmental burden, opening up new prospects for stratification and the development of personalized treatments tailored to each developmental profile.
神经发育维度是精准精神病学未来面临的一项重大挑战。它提供了一个跨诊断框架,使得能够超越传统诊断类别(如自闭症谱系障碍、注意力缺陷多动障碍、精神分裂症和双相情感障碍)对精神疾病进行重新定义。该模型基于在关键易损期识别大脑发育轨迹中的偏差。通过整合临床、生物学、神经影像学和神经生理学数据的多模态方法,此框架旨在定义个体化的神经发育负担,为分层以及针对每种发育概况制定个性化治疗方案开辟新前景。