Byanju Riwaj, Kotek Gyula, Vogel Mika W, Klein Stefan, Hernandez-Tamames Juan A, Poot Dirk H J
Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, The Netherlands.
GE Healthcare, Hoevelaken, The Netherlands.
MAGMA. 2025 May 26. doi: 10.1007/s10334-025-01262-2.
This study presents the 3D MP-b-nSSFP sequence for multi-parametric mapping.
We evaluate several aspects of the 3D implementation, like the type of RF pulse (selective/non-selective), the readout duration, the undersampling pattern, and the acceleration factor. We use undersampled scans with subspace-constrained reconstruction and extended spiral readouts to achieve clinically acceptable scan times. The repeatability and accuracy of the and maps are compared with a reference technique in phantom and three volunteer scans.
Compared with selective refocusing pulses, we observe lower bias with non-selective pulses, despite modeling the spatially varying effect of the pulses in the fitting process. and maps obtained from phantom scans were comparable to the nominal values and those from reference scans. values in vivo were underestimated compared to the reference scan. The maps with an acquisition matrix of and resolution were acquired in 11 min.
We show that 3D MP-b-nSSFP can be used for multi-parameter mapping within clinically acceptable scan time. Phantom scans show results in good agreement with reference scan results. However, the in vivo scan underestimated .
本研究介绍了用于多参数映射的3D MP-b-nSSFP序列。
我们评估了3D实现的几个方面，如射频脉冲类型（选择性/非选择性）、读出持续时间、欠采样模式和加速因子。我们使用具有子空间约束重建和扩展螺旋读出的欠采样扫描来实现临床可接受的扫描时间。在体模和三次志愿者扫描中，将 和 图的重复性和准确性与参考技术进行比较。
与选择性重聚焦脉冲相比，尽管在拟合过程中对脉冲的空间变化效应进行了建模，但我们观察到非选择性脉冲的偏差更低。从体模扫描获得的 和 图与标称值以及参考扫描的图相当。与参考扫描相比，体内 值被低估。采集矩阵为 且分辨率为 的图在11分钟内获得。
我们表明3D MP-b-nSSFP可用于在临床可接受的扫描时间内进行多参数映射。体模扫描结果与参考扫描结果高度一致。然而，体内扫描低估了 。
