Hodgson Philip, Jordan Alastair, Sinani Charikleia, Charura Divine
Physiotherapy Department, Tees, Esk and Wear Valleys NHS Foundation Trust, West Park Hospital, Darlington, UK.
School of Science, Technology and Health, York St John University, York, UK.
Brain Behav. 2025 May;15(5):e70563. doi: 10.1002/brb3.70563.
Parkinson's disease (PD) is a complex neurological disorder characterized by both motor and nonmotor symptoms, including tremor, muscle stiffness, anxiety, and depression.
The primary aim of this study was to examine the relationship between physical function and psychological symptoms, specifically anxiety and depression, in people with Parkinson's (PwP). The secondary aim was to explore whether any discrepancies between participant-reported and clinician-rated measures of physical function exist.
This study utilized the Parkinson's Progression Markers Initiative (PPMI) dataset, analyzing data from 1065 individuals with PD. Correlational analyses assessed relationships between clinician-rated and participant-reported motor outcomes alongside psychological symptoms. Multiple linear regression (MLR) was employed to identify predictors of anxiety and depression.
In PwP, significant correlations were found between depression/anxiety and participant-reported motor function (via MDS-UPDRS Part II: r = 0.313 for depression, r = 0.284 for anxiety, p < 0.05). In contrast, correlations with clinician-rated motor function (via MDS-UPDRS Part III) were weaker (r = 0.079 for depression, p < 0.05; r = 0.054 for anxiety, p = 0.08). MLR analysis indicated that in PwP, age, cognition, and participant-reported motor function explained 11.2% of the variance in depression and 10.5% in anxiety.
This study highlights a discrepancy between psychological symptoms and their relationship with clinician-rated versus participant-reported motor function in PwP. Our findings suggest that factors such as age, cognitive level, and perceived physical function significantly influence this relationship. Consequently, it is crucial to consider psychological factors and participant-reported motor function when conducting clinical assessments and treatment planning for individuals with PD.
帕金森病（PD）是一种复杂的神经疾病，其特征为运动和非运动症状，包括震颤、肌肉僵硬、焦虑和抑郁。
本研究的主要目的是检验帕金森病患者（PwP）的身体功能与心理症状（特别是焦虑和抑郁）之间的关系。次要目的是探讨参与者报告的和临床医生评定的身体功能测量之间是否存在差异。
本研究使用了帕金森病进展标志物计划（PPMI）数据集，分析了1065名帕金森病患者的数据。相关性分析评估了临床医生评定的和参与者报告的运动结果与心理症状之间的关系。采用多元线性回归（MLR）来确定焦虑和抑郁的预测因素。
在PwP中，抑郁/焦虑与参与者报告的运动功能之间存在显著相关性（通过MDS-UPDRS第二部分：抑郁的r = 0.313，焦虑的r = 0.284，p < 0.05）。相比之下，与临床医生评定的运动功能（通过MDS-UPDRS第三部分）的相关性较弱（抑郁的r = 0.079，p < 0.05；焦虑的r = 0.054，p = 0.08）。MLR分析表明，在PwP中，年龄、认知和参与者报告的运动功能解释了抑郁变异的11.2%和焦虑变异的10.5%。
本研究突出了PwP中心理症状及其与临床医生评定的和参与者报告的运动功能之间关系的差异。我们的研究结果表明，年龄、认知水平和感知到的身体功能等因素显著影响这种关系。因此，在对帕金森病患者进行临床评估和治疗规划时，考虑心理因素和参与者报告的运动功能至关重要。
