Torbati D, Lo P, Lambertsen C J
Neurosci Lett. 1984 Sep 7;50(1-3):79-84. doi: 10.1016/0304-3940(84)90466-x.
Previous studies have shown significant increases in regional cerebral metabolic rate for glucose (rCMRgl) in 14 of 28 investigated brain structures in rats exposed to 1-h oxygen at 2 atmosphere absolute (ATA O2). Continuous 4-h exposure to 2 ATA O2 resulted in significant increases only in superior olivary nucleus and inferior colliculus. In the present study, the rCMRgl was autoradiographically measured by the [14C]2-deoxyglucose technique during the last 30 min of 4 intermittent 1-h exposures to either 2 ATA O2 or air at atmospheric pressure, with 3 h of breathing air outside the pressure chamber between each oxygen or air exposure. Statistically significant reductions in rCMRgl of the oxygen-exposed rats were observed in superior olivary nucleus and inferior colliculus, while no changes were observed in 26 other investigated structures. The previously observed increases in rCMRgl in a single 1- or 4-h exposure at 2 ATA O2 were reduced or reversed during the intermittent hyperbaric oxygen exposure. The relation of the observed changes in rCMRgl during single and intermittent hyperbaric oxygen exposures to the extension of tolerance to hyperbaric oxygenation is discussed.
先前的研究表明，在暴露于2个绝对大气压氧气（2 ATA O2）1小时的大鼠中，28个被研究脑结构中的14个区域脑葡萄糖代谢率（rCMRgl）显著增加。持续4小时暴露于2 ATA O2仅导致上橄榄核和下丘显著增加。在本研究中，通过[14C]2-脱氧葡萄糖技术在4次间歇性1小时暴露于2 ATA O2或常压空气的最后30分钟内进行放射自显影测量rCMRgl，每次氧气或空气暴露之间在压力室外呼吸空气3小时。在暴露于氧气的大鼠中，上橄榄核和下丘的rCMRgl出现统计学显著降低，而在其他26个被研究结构中未观察到变化。先前观察到的在2 ATA O2下单次1小时或4小时暴露时rCMRgl的增加在间歇性高压氧暴露期间减少或逆转。讨论了单次和间歇性高压氧暴露期间观察到的rCMRgl变化与高压氧耐受性延长之间的关系。
