Ferrer J M, Myers R D, Mora F
Brain Res Bull. 1985 Aug;15(2):225-8. doi: 10.1016/0361-9230(85)90141-8.
The question of whether neurons versus fibers of passage in the medial prefrontal cortex (MPC) are essential in maintaining self-stimulation of this same area of the brain was examined. Rats were prepared with electrode-guide cannulae implanted stereotaxically to rest within MPC. A micro-injection of (KA), 10 nmol/1.0 microliter, into the right MPC produced a clear degeneration of neuronal cell bodies characterized by picnocytosis and glial invasion of the tissue surrounding the tip of the electrode. These histopathological changes were correlated with a permanent abolition of self-stimulation of the right MPC. In contrast, self-stimulation of the contralateral side of the MPC, micro-injected with 0.9% NaCl vehicle as a control, was unaffected. These results suggest that neurons of the MPC are part of the neural substrate underlying self-stimulation behavior in this cortical area of the rat.
研究了内侧前额叶皮质（MPC）中的神经元与传导纤维对于维持该脑区自我刺激是否至关重要。通过立体定位植入电极引导套管，使大鼠在MPC内休息。向右侧MPC微量注射10 nmol/1.0微升的谷氨酸钾（KA），导致神经元细胞体明显变性，其特征为核固缩和电极尖端周围组织的胶质细胞浸润。这些组织病理学变化与右侧MPC自我刺激的永久消除相关。相比之下，作为对照，向对侧MPC微量注射0.9%氯化钠载体后，其自我刺激未受影响。这些结果表明，MPC中的神经元是大鼠该皮质区域自我刺激行为潜在神经基质的一部分。
