Ferrer J M, Sabater R, Saez J A
Department of Physiology, School of Medicine, University of Granada, Spain.
Eur J Pharmacol. 1993 Jan 26;231(1):39-45. doi: 10.1016/0014-2999(93)90681-7.
The effects of intracerebral microinjections of neurotensin and xenopsin on self-stimulation of the medial prefrontal cortex of the rat were studied. Unilateral microinjections into the medial prefrontal cortex of neurotensin at doses of 0.625, 1.25, 2.5, 5 and 10 nmol produced a dose-related decrease of self-stimulation in the ipsilateral medial prefrontal cortex. Self-stimulation of the contralateral medial prefrontal contex, used as control, was not affected by the microinjections. Similar results were found with the neurotension-like octapeptide, xenopsin. Unilateral microinjections of xenoposin into the medial prefrontal cortex, at doses of 1.8, 3.6, 7.2 and 14.4 nmol produced a dose-related decrease of self-stimulation of the ipsilateral medial prefrontal cortex. Self-stimulation of the contralateral medial prefrontal cortex was not affected. These results suggest that neurotensin is part of the neurochemical substrate of self-stimulation in this cortical area.
研究了向大鼠内侧前额叶皮质脑内微量注射神经降压素和异视蛋白对自我刺激的影响。以0.625、1.25、2.5、5和10纳摩尔的剂量向内侧前额叶皮质单侧微量注射神经降压素，导致同侧内侧前额叶皮质的自我刺激呈剂量相关下降。作为对照的对侧内侧前额叶皮质的自我刺激不受微量注射的影响。对于类神经降压素八肽异视蛋白也发现了类似结果。以1.8、3.6、7.2和14.4纳摩尔的剂量向内侧前额叶皮质单侧微量注射异视蛋白，导致同侧内侧前额叶皮质的自我刺激呈剂量相关下降。对侧内侧前额叶皮质的自我刺激不受影响。这些结果表明，神经降压素是该皮质区域自我刺激的神经化学底物的一部分。
