Robertson K, Douglas M J, McMorland G H
Can Anaesth Soc J. 1985 Sep;32(5):502-5. doi: 10.1007/BF03010800.
Using a double-bolus technique, the efficacy and safety of epidural fentanyl with and without epinephrine 1:400,000 for post-Caesarean section analgesia was examined in 30 patients. The addition of 25 micrograms epinephrine to the fentanyl (100 micrograms) did not potentiate the speed of onset but did significantly prolong the duration of action of the second dose. The only side effect encountered was pruritus, which was significantly increased (from 17-44 per cent) when epinephrine was added. The results indicate a clinical advantage of prolonging the duration of action of fentanyl for post-Caesarean Section analgesia with the addition of epinephrine, but the cumbersome and time-consuming nature of a double-bolus technique limits its clinical value. The relative safety of epidural fentanyl with and without epinephrine was confirmed by the absence of respiratory depression, drowsiness or hypotension in all patients.
采用双剂量注射技术，对30例剖宫产术后患者使用含或不含1:400,000肾上腺素的硬膜外芬太尼进行镇痛的疗效和安全性进行了研究。在芬太尼（100微克）中加入25微克肾上腺素并未加快起效速度，但显著延长了第二剂的作用持续时间。唯一出现的副作用是瘙痒，加入肾上腺素后瘙痒发生率显著增加（从17%增至44%）。结果表明，加入肾上腺素可延长芬太尼在剖宫产术后镇痛中的作用持续时间，具有临床优势，但双剂量注射技术繁琐且耗时，限制了其临床价值。所有患者均未出现呼吸抑制、嗜睡或低血压，证实了含或不含肾上腺素的硬膜外芬太尼相对安全。
