Tang Haishuang, Wang Kaiwen, Zheng Kaige, Wen Zheng, Yang Yi, Mo Shaohua, Nie Xin, Lan Chuanjin, Liu Qingyuan, Wang Shuo
Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People's Republic of China.
China National Clinical Research Center for Neurological Diseases, Beijing, People's Republic of China.
Sci Rep. 2025 May 26;15(1):18359. doi: 10.1038/s41598-025-03583-7.
The triglyceride-glucose (TyG) index, a marker of insulin resistance, reflects combined lipid and glucose dysregulation, which may exacerbate severe spontaneous intracerebral hemorrhage (SSICH) outcomes. The association of TyG index and postoperative outcome of SSICH patients hasn't been extensively studied. This study aimed to investigate whether the high TyG index was associated with increased risk of poor outcomes in SSICH patients. This study included SSICH patients from a multicenter, prospective cohort study in China from September 2019 to December 2022. TyG index was calculated on admission and the 7th day after surgery and all patients were categorized as Q1 to Q4 according to the interquartile ranges (IQRs) of TyG index. The primary outcome was the incidence of major adverse cardiovascular and cerebrovascular events (MACCE) within 180 days after hemorrhage. This study included 761 SSICH patients receiving surgery with a median admission TyG index of 7.2 (IQR, 6.7-7.6). MACCE occurred in 131 (17.2%) patients within 180 days after SSICH. The results showed that a high TyG index is related to a high incidence of 180-day MACCE events (odds ratio, 2.36, per 1 unit; 95% CI: 1.82, 2.06; P < 0.001), and the risk of 180-day MACCE events significantly increased with the TyG index from Q1 to Q4 (P for trend < 0.001). The further analysis of TyG index on the 7th day after surgery reveal the similar results between TyG index and 180-day clinical outcomes (P < 0.001). This study revealed that high TyG index was associated with the risk of poor outcomes in SSICH patients after surgery, which may serve as an effective and stable indicator for clinical monitoring.
甘油三酯-葡萄糖（TyG）指数是胰岛素抵抗的一个指标，反映了脂质和葡萄糖的联合失调，这可能会加重严重自发性脑出血（SSICH）的预后。TyG指数与SSICH患者术后预后的关系尚未得到广泛研究。本研究旨在调查高TyG指数是否与SSICH患者不良预后风险增加有关。本研究纳入了2019年9月至2022年12月在中国进行的一项多中心前瞻性队列研究中的SSICH患者。在入院时和术后第7天计算TyG指数，并根据TyG指数的四分位数间距（IQR）将所有患者分为Q1至Q4组。主要结局是出血后180天内发生的主要不良心血管和脑血管事件（MACCE）的发生率。本研究纳入了761例接受手术的SSICH患者，入院时TyG指数中位数为7.2（IQR，6.7-7.6）。131例（17.2%）患者在SSICH后180天内发生MACCE。结果显示，高TyG指数与180天MACCE事件的高发生率相关（优势比，2.36，每1个单位；95%CI：1.82，2.06；P < 0.001），并且随着TyG指数从Q1到Q4，180天MACCE事件的风险显著增加（趋势P < 0.001）。术后第7天TyG指数的进一步分析显示，TyG指数与180天临床结局之间的结果相似（P < 0.001）。本研究表明，高TyG指数与SSICH患者术后不良预后风险相关，这可能作为临床监测的一个有效且稳定指标。
