McEwen S A, Valli V E, Hulland T J
Can J Comp Med. 1985 Jul;49(3):248-53.
The clinical, clinicopathological and pathological findings in three cats with hypereosinophilic syndrome are described. The cats chosen for the study had marked eosinophilia and evidence of tissue infiltration by eosinophils. Necropsies were performed on two cats, biopsy and blood samples were provided for the third cat. At necropsy, there was diffuse reddening of femoral bone marrow with ulceration and thickening of the duodenum. The livers had an enhanced lobular pattern with multiple, white, 1-3 mm nodules throughout the parenchyma. One cat had splenomegaly and the other had several enlarged, white, firm lymph nodes. Histopathologically, there was eosinophil infiltration of intestine, lymph nodes, liver, spleen, adrenal medulla and beneath the endocardium. Ultrastructurally, the eosinophils from lymph node and bone marrow of cat II were morphologically normal. The rigid criteria for eosinophilic leukemia were not fulfilled by these cases and the etiology of the eosinophilia in each case is not known. Possible pathogenic mechanisms are discussed.
描述了三只患有嗜酸性粒细胞增多综合征猫的临床、临床病理和病理表现。所选用于研究的猫有明显的嗜酸性粒细胞增多以及嗜酸性粒细胞组织浸润的证据。对两只猫进行了尸检，为第三只猫提供了活检和血液样本。尸检时，股骨骨髓弥漫性发红，十二指肠有溃疡和增厚。肝脏小叶模式增强，整个实质内有多个1 - 3毫米的白色结节。一只猫有脾肿大，另一只猫有几个肿大、白色、坚硬的淋巴结。组织病理学上，在肠道、淋巴结、肝脏、脾脏、肾上腺髓质和心内膜下有嗜酸性粒细胞浸润。超微结构上，猫II的淋巴结和骨髓中的嗜酸性粒细胞形态正常。这些病例未满足嗜酸性粒细胞白血病的严格标准，且每个病例中嗜酸性粒细胞增多的病因尚不清楚。讨论了可能的致病机制。
