Rodríguez L M, López A, Merino-Moncada M, Martínez-Burnes J, Mondragón I
Can J Comp Med. 1985 Jul;49(3):323-6.
The aim of this investigation was to do a comparative study on the deposition and clearance of inhaled bacteria between the lungs and tracheae of mice exposed to aerosols of bacteria. Two hundred and eighty-eight mice were divided into four groups (n = 72) and exposed to aerosols of Pasteurella haemolytica or Staphylococcus aureus in four replicates. The numbers of bacteria were determined in the trachea and lungs of mice sacrificed 0, 2, 4, 8, 12, 24, 48 and 72 hours postexposure. Results indicated that bacterial deposition was greater in lungs than in tracheae. No significant (p greater than 0.05) difference was observed between P. haemolytica and S. aureus clearance rates. Although bacteria were rapidly eliminated from the whole respiratory tract, bacterial clearance was significantly (p less than 0.002) faster in tracheae than lungs. A significant (p less than 0.05) replicate effect was also observed.
本研究的目的是对暴露于细菌气溶胶的小鼠肺部和气管中吸入细菌的沉积和清除情况进行比较研究。288只小鼠被分为四组（每组n = 72），并分四次重复暴露于溶血巴斯德菌或金黄色葡萄球菌气溶胶中。在暴露后0、2、4、8、12、24、48和72小时处死小鼠，测定其气管和肺部的细菌数量。结果表明，肺部的细菌沉积量大于气管。溶血巴斯德菌和金黄色葡萄球菌的清除率之间未观察到显著差异（p>0.05）。尽管细菌能从整个呼吸道迅速清除，但气管中的细菌清除速度明显快于肺部（p<0.002）。还观察到显著的重复效应（p<0.05）。
