Han Yu, Xu Rui-Si, Zhou Xiang-Yi, Yang Xiao-Huang-Hao, Chen Rui-Yi, Lin Qian-Qian, Shen Zhi-Hua, Wang Yong-Guang
Affiliated Mental Health Center & Hangzhou Seventh People's Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China.
School of Mental Health and Psychological Sciences, Anhui Medical University, Hefei, Anhui Province, China.
BMC Psychiatry. 2025 May 26;25(1):548. doi: 10.1186/s12888-025-06999-7.
We investigated alterations in impulsive choice and impulsive action among individuals with methamphetamine use disorder (MUD) compared to a control group after exposure to cues associated with methamphetamine (METH).
Thirty-four participants with MUD and 31 healthy participants were instructed to experience a METH-related virtual reality (VR) social environment and to perform the go/no-go task as well as the balloon analog risk task (BART) before (the baseline condition) and after (the cue-induced condition) watching a VR video.
There were no significant differences between groups for go/no-go task both in the baseline condition and cue-induced condition. The METH group exhibited more adjusted pumps in the cue-induced condition than in the baseline condition. The λ (loss aversion) of the METH group was significantly lower in the cue-induced condition than in the baseline condition. In the correlation analysis of behavioral data and the exponential-weight mean-variance (EWMV) parameters, λ was the only parameter related to adjusted pumps both in the baseline condition and the cue-induced condition, reflected by a strong negative correlation.
These findings suggest that METH related cues may impact impulsive choice, but not impulsive action, by decreasing loss aversion.
我们调查了甲基苯丙胺使用障碍（MUD）个体与对照组在接触与甲基苯丙胺（METH）相关的线索后，冲动选择和冲动行为的变化。
34名患有MUD的参与者和31名健康参与者被要求体验与METH相关的虚拟现实（VR）社交环境，并在观看VR视频之前（基线条件）和之后（线索诱导条件）执行停止信号任务以及气球模拟风险任务（BART）。
在基线条件和线索诱导条件下，两组在停止信号任务上均无显著差异。METH组在线索诱导条件下比基线条件下表现出更多的调整后打气次数。METH组的λ（损失厌恶）在线索诱导条件下显著低于基线条件。在行为数据与指数加权均值 - 方差（EWMV）参数的相关性分析中，λ是在基线条件和线索诱导条件下与调整后打气次数相关的唯一参数，表现为强负相关。
这些发现表明，与METH相关的线索可能通过降低损失厌恶来影响冲动选择，但不影响冲动行为。
