Liu Baokun, Zhang Jiming, Liu Wen, Zhou Dong, Qu Ruisheng, Gu Hao, Guo Tingting, He Jinwei, Pei Yanan, Wang Qihua, Wang Tingmei, Zhang Yaoming
Lanzhou University Second Hospital, Lanzhou, 730000, P. R. China.
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, P. R. China.
Adv Healthc Mater. 2025 Jul;14(18):e2501467. doi: 10.1002/adhm.202501467. Epub 2025 May 27.
Hydrogels are recognized for their excellent biocompatibility and biodegradability, making them promising candidates for hemostatic materials, especially in cases of intra-abdominal bleeding or injury to vital organs. In this study, a mussel-inspired adhesive hemostatic hydrogel, GMOD, is developed, which features injectability, outstanding biocompatibility, and biodegradability. The hydrogel is synthesized through Schiff base crosslinking of oxidized dextran and gelatin, enhanced with dopamine to form a robust double network structure. This unique double network not only provides mechanical stability but also significantly enhances tissue adhesion as well as the adhesion of red blood cells and platelets, resulting in a 76% reduction in bleeding in a mouse liver hemorrhage model. Additionally, the incorporation of vascular endothelial growth factor (VEGF) into GMOD enables sustained release, promoting skin wound healing and reducing inflammatory responses in mice. In summary, a highly adhesive, injectable, and rapid hemostatic hydrogel is presented that demonstrates considerable potential for use in intra-abdominal hemostasis, leveraging the advantages of a double network structure to enhance its performance.
水凝胶因其出色的生物相容性和生物降解性而受到认可，这使其成为止血材料的有前景的候选者，特别是在腹腔内出血或重要器官损伤的情况下。在本研究中，开发了一种受贻贝启发的粘性止血水凝胶GMOD，其具有可注射性、出色的生物相容性和生物降解性。该水凝胶通过氧化葡聚糖和明胶的席夫碱交联合成，用多巴胺增强以形成坚固的双网络结构。这种独特的双网络不仅提供机械稳定性，还显著增强组织粘附以及红细胞和血小板的粘附，在小鼠肝出血模型中使出血减少76%。此外，将血管内皮生长因子（VEGF）掺入GMOD可实现持续释放，促进小鼠皮肤伤口愈合并减少炎症反应。总之，提出了一种高粘性、可注射且快速止血的水凝胶，其利用双网络结构的优势来增强性能，在腹腔内止血方面显示出巨大的应用潜力。
