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免疫刺激对自身炎症性疾病的影响。慢性复发性多灶性骨髓炎病例报告及文献综述：一例病例报告。

Impact of immunostimulation on autoinflammatory disease. CRMO case presentation and literature review: A case report.

作者信息

Munteanu Andrei-Ioan, Nicoară Delia-Maria, Jugănaru Iulius, Bugi Meda-Ada, Mărginean Otilia

机构信息

Department XI Pediatrics, Discipline I Pediatrics, 'Victor Babes' University of Medicine and Pharmacy of Timisoara, 300041 Timisoara, Romania.

1st Department of Pediatrics, Children's Emergency Hospital 'Louis Turcanu', 300011 Timisoara, Romania.

出版信息

Biomed Rep. 2025 May 13;23(1):115. doi: 10.3892/br.2025.1993. eCollection 2025 Jul.

DOI:10.3892/br.2025.1993
PMID:40420973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12105086/
Abstract

Chronic recurrent multifocal osteomyelitis (CRMO) is a rare bone condition included in the spectrum of autoinflammatory pediatric rheumatological diseases. In the present case report, a 9-year-old female patient with a personal history of psoriasis since the age of 5 presented with left clavicle pain persisting for ~2 months. Following thorough anamnesis and investigations carried out, a diagnosis of CRMO was established. The present case report discusses a rare pediatric autoinflammatory pathology with autoimmune implications, emphasizing the role of immunostimulation/immune dysfunction. It is possible that immunostimulation with (also known as ) for psoriasis management may underlie the development of autoinflammatory-destructive bone lesions. Establishing causal relationships between immunological, bacterial and autoinflammatory factors was challenging during the patient's evaluation in our service.

摘要

慢性复发性多灶性骨髓炎（CRMO）是一种罕见的骨骼疾病，属于儿童自身炎症性风湿性疾病范畴。在本病例报告中，一名9岁女性患者自5岁起就有银屑病个人史，出现左侧锁骨疼痛持续约2个月。经过全面的病史采集和检查后，确诊为CRMO。本病例报告讨论了一种罕见的具有自身免疫影响的儿童自身炎症性病理学，强调了免疫刺激/免疫功能障碍的作用。用于银屑病治疗的（也称为）免疫刺激可能是自身炎症性破坏性骨病变发展的基础。在我们科室对该患者的评估过程中，确定免疫、细菌和自身炎症因素之间的因果关系具有挑战性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/f8e2e446b422/br-23-01-01993-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/eea4be0c2e36/br-23-01-01993-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/a423df6de915/br-23-01-01993-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/a6071f5cb8a1/br-23-01-01993-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/afb04edf0682/br-23-01-01993-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/6029af7d5783/br-23-01-01993-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/8e8c016be272/br-23-01-01993-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/f8e2e446b422/br-23-01-01993-g06.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/eea4be0c2e36/br-23-01-01993-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/a423df6de915/br-23-01-01993-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/a6071f5cb8a1/br-23-01-01993-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/afb04edf0682/br-23-01-01993-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/6029af7d5783/br-23-01-01993-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/8e8c016be272/br-23-01-01993-g05.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e23/12105086/f8e2e446b422/br-23-01-01993-g06.jpg

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Classification and management strategies for paediatric chronic nonbacterial osteomyelitis and chronic recurrent multifocal osteomyelitis.儿童慢性非细菌性骨髓炎和慢性复发性多灶性骨髓炎的分类及管理策略
Expert Rev Clin Immunol. 2023 Jul-Dec;19(9):1101-1116. doi: 10.1080/1744666X.2023.2218088. Epub 2023 Jun 7.
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Chronic Nonbacterial Osteomyelitis and Inflammatory Bowel Disease: A Literature Review-Based Cohort.
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Children (Basel). 2023 Mar 3;10(3):502. doi: 10.3390/children10030502.
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The NLRP3 inflammasome as a target for sensorineural hearing loss.NLRP3炎性小体作为感音神经性听力损失的一个靶点。
Clin Immunol. 2023 Apr;249:109287. doi: 10.1016/j.clim.2023.109287. Epub 2023 Mar 11.
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Chronic Recurrent Multifocal Osteomyelitis (CRMO) and Juvenile Spondyloarthritis (JSpA): To What Extent Are They Related?慢性复发性多灶性骨髓炎（CRMO）与青少年脊柱关节炎（JSpA）：它们在多大程度上相关？
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