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用于马匹伤口现场治疗与监测的易于应用的水凝胶贴片。

Easy-to-Apply Hydrogel Patch for Field Treatment and Monitoring of Equine Wounds.

作者信息

Zambroni María Emilia, Bertone Patricia A, Cabral Ana Lucía, Boatti Andrés S, Romanini Silvia V, Martínez Sol R, Gómez María Lorena

机构信息

Instituto de Investigaciones en Tecnologías Energéticas y Materiales Avanzados (IITEMA), Universidad Nacional de Río Cuarto and Consejo Nacional de Investigaciones Científicas y Tecnológicas (CONICET), Campus Universitario, Río Cuarto 5800, Argentina.

Departamento de Clínica Animal, Facultad de Agronomía y Veterinaria, Universidad Nacional de Río Cuarto, Campus Universitario, Río Cuarto 5800, Argentina.

出版信息

Gels. 2025 Apr 27;11(5):328. doi: 10.3390/gels11050328.

Abstract

The cicatrization process, which is critical to equine health, directly affects overall well-being by preventing infection, minimizing tissue damage, and restoring optimal function. Herein, we present a case of a 5-year-old sorrel mare with a torn skin wound on the dorsal aspect of the metatarsal region of the left hind limb, treated locally with an antibiotic-free transparent hydrogel-based patch while monitoring its healing process. The patch induced pink granulation tissue in the treated area after 42 days, while keloid formation was observed in the untreated area. Wound measurements showed a reduction over time with patch treatment, with complete healing achieved at 116 days. Capillary formation and a velvety appearance were observed on day 80. Histological analysis revealed mature granulation tissue, fibrocyte formation, abundant capillaries, organized collagen fibrils, and development of type III collagen in the treated area. Interestingly, no inflammatory response was observed during treatment. The hydrogel patch not only accelerated healing, but also controlled excessive granulation tissue formation. This treatment represents an innovative approach to equine wound management that updates applications for owners while reducing costs.

摘要

瘢痕形成过程对马的健康至关重要,它通过预防感染、减少组织损伤和恢复最佳功能直接影响整体健康状况。在此,我们报告一例5岁的栗色母马,其左后肢跖骨区域背侧有一处皮肤撕裂伤,在监测其愈合过程的同时,局部使用不含抗生素的透明水凝胶贴片进行治疗。42天后,贴片在治疗区域诱导出粉红色肉芽组织,而未治疗区域观察到瘢痕疙瘩形成。伤口测量显示,贴片治疗后伤口随时间缩小,116天时实现完全愈合。在第80天观察到毛细血管形成和天鹅绒样外观。组织学分析显示,治疗区域有成熟的肉芽组织、纤维细胞形成、丰富的毛细血管、有组织的胶原纤维以及III型胶原的发育。有趣的是,治疗期间未观察到炎症反应。水凝胶贴片不仅加速了愈合,还控制了过度肉芽组织的形成。这种治疗方法代表了一种创新的马伤口管理方法,既为马主更新了应用方式,又降低了成本。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2bc6/12111212/9d3ade7082ca/gels-11-00328-g001.jpg

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