Alberts Adina, Tudorache Dana-Ionela, Niculescu Adelina-Gabriela, Grumezescu Alexandru Mihai
Carol Davila University of Medicine and Pharmacy, 050474 Bucharest, Romania.
National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania.
Gels. 2025 Feb 7;11(2):123. doi: 10.3390/gels11020123.
Recent advancements in wound dressing materials have significantly improved acute and chronic wound management by addressing challenges such as infection control, moisture balance, and enhanced healing. Important progress has been made, especially with hydrogels, foams, and antimicrobial materials for creating optimized dressings. Hydrogels are known for maintaining optimal moisture levels, while foam dressings are excellent exudate absorbents. Meanwhile, antimicrobial dressing incorporates various antimicrobial agents to reduce infection risks. These dressing options reduce wound healing time while focusing on customized patient needs. Therefore, this review highlights the newest research materials and prototypes for wound healing applications, emphasizing their particular benefits and clinical importance. Innovations such as stimuli-responsive hydrogels and hybrid bioengineered composites are discussed in relation to their enhanced properties, including responsiveness to pH, temperature, glucose, or enzymes and drug delivery precision. Moreover, ongoing clinical trials have been included, demonstrating the potential of emerging solutions to be soon translated from the laboratory to clinical settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, and biological insights, this work provides a contemporary framework for patient-centric, efficient wound care strategies.
伤口敷料材料的最新进展通过应对感染控制、水分平衡和促进愈合等挑战,显著改善了急性和慢性伤口的处理。尤其是在用于制作优化敷料的水凝胶、泡沫材料和抗菌材料方面取得了重要进展。水凝胶以保持最佳水分水平而闻名,而泡沫敷料是出色的渗出液吸收剂。同时,抗菌敷料包含各种抗菌剂以降低感染风险。这些敷料选择在关注患者个性化需求的同时,缩短了伤口愈合时间。因此,本综述重点介绍了用于伤口愈合应用的最新研究材料和原型,强调了它们的特殊益处和临床重要性。讨论了诸如刺激响应性水凝胶和混合生物工程复合材料等创新,涉及其增强的特性,包括对pH值、温度、葡萄糖或酶的响应以及药物递送精度。此外,还纳入了正在进行的临床试验,展示了新兴解决方案从实验室迅速转化为临床应用的潜力。通过讨论整合先进材料、纳米技术和生物学见解的跨学科方法,这项工作为以患者为中心的高效伤口护理策略提供了一个当代框架。
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