Merkis Mantvydas, Slektaite-Kisone Akvile, Burkanas Marius, Cicinas Aleksandras, Dziugelis Mindaugas, Klimkevicius Vaidas, Adliene Diana, Venius Jonas
Department of Physics, Kaunas University of Technology, Studentų g. 50, LT-51368 Kaunas, Lithuania.
Medical Physics Department, National Cancer Center, Affiliate of Vilnius University Hospital Santaros Klinikos, Santariškių g. 1, LT-08406 Vilnius, Lithuania.
Gels. 2025 Apr 30;11(5):336. doi: 10.3390/gels11050336.
FLASH radiation therapy is an emerging technique that provides several advantages over conventional radiotherapy. By delivering ultra-high dose rate radiation, the damage to healthy tissues surrounding the treatment area is minimized, treatment time is reduced and treatment outcomes of radioresistant tumors are improved. Despite its promising potential, FLASH radiation therapy remains relatively understudied, particularly in the field of dosimetry. Polymer gel dosimetry is a promising technique for verifying FLASH radiation therapy because it enables volumetric dose distribution measurements with high spatial accuracy. This study investigates the applicability of two commonly used polymer gel dosimeters, nPAG and NIBMAGAT, enhanced with nanoparticles, in ultra-high dose rate radiation therapy. The results indicate that NIBMAGAT gel, enriched with Ag nanoparticles, outperforms nPAG. NIBMAGAT gel exhibits less saturation at high doses, maintains dose rate independence and offers comparable sensitivity to nPAG formulation.
闪速放射治疗是一种新兴技术，与传统放射治疗相比具有多个优势。通过提供超高剂量率辐射，可将治疗区域周围健康组织的损伤降至最低，减少治疗时间，并改善抗辐射肿瘤的治疗效果。尽管闪速放射治疗具有广阔的前景，但相对而言研究较少，尤其是在剂量测定领域。聚合物凝胶剂量测定法是一种很有前景的验证闪速放射治疗的技术，因为它能够以高空间精度进行体积剂量分布测量。本研究调查了两种常用的、用纳米颗粒增强的聚合物凝胶剂量计nPAG和NIBMAGAT在超高剂量率放射治疗中的适用性。结果表明，富含银纳米颗粒的NIBMAGAT凝胶优于nPAG。NIBMAGAT凝胶在高剂量下饱和度较低，保持剂量率独立性，并且对nPAG配方具有相当的灵敏度。
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