Altenburger Markus Jörg, Bergmann Michael Eckhard, Ledernez Loic Alain, Romanos Georgios
Department of Orthodontics, Center for Dental Medicine, Medical Center-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.
Department of Operative Dentistry and Periodontology, Center for Dental Medicine, Medical Center-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Straße 55, 79106 Freiburg, Germany.
Dent J (Basel). 2025 May 14;13(5):210. doi: 10.3390/dj13050210.
This study evaluated the effectiveness of a new cold atmospheric plasma device (AmbiJet) for eradicating mature oral biofilm on titanium implant surfaces, aiming to improve decontamination methods for the treatment of peri-implant infections. Mature oral biofilms were grown on titanium disks placed in participants' mouths. These disks were divided into control and plasma treatment groups. The AmbiJet device delivered plasma directly to the implant surface for 3 min per 20 mm, utilizing the applicator nozzle and implant as electrodes. Biofilm reduction was quantified by counting colony-forming units (CFUs). Cold plasma treatment rendered approximately 90% of samples bacteria-free. A > 6-log reduction (≈99.9999%) in bacterial load was achieved in 30% of samples, with an overall average reduction of 4.9-log across all treated samples. The temperature during treatment remained below 40 °C. Within the study's limitations, cold atmospheric plasma effectively eradicates mature oral biofilm on titanium surfaces. This high disinfection efficacy is likely due to the combined action of reactive species and electrical phenomena, which does not cause significant temperature increases.
本研究评估了一种新型冷大气等离子体设备（AmbiJet）在消除钛种植体表面成熟口腔生物膜方面的有效性，旨在改进种植体周围感染治疗的去污方法。成熟的口腔生物膜在置于参与者口腔中的钛盘上生长。这些钛盘被分为对照组和等离子体治疗组。AmbiJet设备利用涂抹器喷嘴和种植体作为电极，将等离子体直接输送到种植体表面，每20毫米处理3分钟。通过计算菌落形成单位（CFU）对生物膜减少情况进行量化。冷等离子体处理使约90%的样本无菌。30%的样本实现了细菌载量>6个对数级的减少（≈99.9999%），所有处理样本的总体平均减少量为4.9个对数级。治疗期间温度保持在40°C以下。在该研究的局限性范围内，冷大气等离子体可有效消除钛表面的成熟口腔生物膜。这种高消毒效果可能归因于活性物质和电现象的联合作用，且不会导致显著的温度升高。
