Conservative options for single-tooth replacements in the anterior region include all-ceramic one-retainer resin-bonded fixed dental prostheses (RBFDPs) and three-unit fixed partial dentures (FPDs). This systematic review assessed their clinical outcomes. Following the PRISMA 2020 guidelines, an electronic search of MEDLINE/PubMed was conducted from November 1991 to March 2025 for randomized clinical trials (RCTs), prospective cohort studies (PCSs), and retrospective cohort studies (RCSs). Keywords included dental prosthesis, fixed prosthesis, resin-bonded prosthesis, single-tooth replacement, anterior teeth, all-ceramic, lithium disilicate, monolithic, zirconia, survival rate, and success rate. Failures and complications were analyzed to determine long-term outcomes. The search identified 990 articles, and the full-text review of 54 articles was performed, resulting in 23 studies meeting the inclusion criteria. This review revealed that one-retainer RBFDPs and three-unit FPDs in the anterior region demonstrated high survival and success rates. However, debonding was a common complication in RBFDPs, while framework design issues were noted in FPDs. These outcomes highlight the reliability of both approaches as conservative, all-ceramic, prosthodontic interventions for anterior single-tooth replacements. The consideration of one-retainer RBFDPs and three-unit FPDs is advisable due to their favorable clinical performance and minimal invasiveness.