Ramírez-Gallegos Ignacio, Busquets-Cortes Carla, Paublini Hernán, López-González Ángel Arturo, Martínez-Almoyna-Rifá Emilio, Tárraga López Pedro Juan, Ramírez-Manent José Ignacio
ADEMA-Health Group, University Institute of Health Sciences Research (IUNICS), 07009 Palma, Balearic Islands, Spain.
Faculty of Dentistry, University School ADEMA, 07009 Palma, Balearic Islands, Spain.
Metabolites. 2025 May 21;15(5):343. doi: 10.3390/metabo15050343.
: Metabolic dysfunction-associated steatotic liver disease (MASLD) is a prevalent liver disorder with significant metabolic implications. Metabolic age, determined through bioimpedance analysis, has emerged as a potential indicator of overall metabolic health. The objective of this study is to evaluate the association between metabolic age and MASLD risk scores in a cohort of Spanish workers. : A cross-sectional study was conducted on 8590 Spanish workers who underwent annual occupational health examinations between 2019 and 2020. Metabolic age was determined using bioelectrical impedance analysis, and the Avoidable Lost Life Years (ALLY) index was calculated as the difference between their metabolic and chronological age. MASLD risk was assessed using various validated scales, including the Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), Zhejiang University Index (ZJU), Fatty Liver Disease Index (FLD), and Lipid Accumulation Product (LAP). A multinomial logistic regression analysis was performed to examine the association between metabolic age and MASLD risk scores, adjusting for sociodemographic and lifestyle variables. : Higher metabolic age values were observed in individuals with greater MASLD risk across all evaluated scales. The mean metabolic age was consistently lower in women compared to men, and these differences were statistically significant ( < 0.01). Multinomial logistic regression analysis revealed that the strongest associations with increased metabolic age were found for MASLD risk scores, physical inactivity, and poor adherence to the Mediterranean diet. ROC curve analysis demonstrated a high predictive capacity for the FLD (AUC: 0.935 in women and 0.917 in men) and FLI (AUC: 0.900 in women and 0.833 in men), with high Youden index values. : Metabolic age is significantly associated with MASLD risk, suggesting its potential as a non-invasive biomarker for identifying individuals with a higher risk for metabolic liver disease. Lifestyle factors, including physical activity and dietary patterns, play a crucial role in modulating metabolic age, highlighting the importance of targeted interventions for MASLD prevention. Further research is warranted to validate metabolic age as a prognostic tool in MASLD risk assessment.
代谢功能障碍相关脂肪性肝病（MASLD）是一种普遍存在的肝脏疾病，具有重要的代谢影响。通过生物电阻抗分析确定的代谢年龄已成为整体代谢健康的潜在指标。本研究的目的是评估西班牙一组工人中代谢年龄与MASLD风险评分之间的关联。：对8590名在2019年至2020年间接受年度职业健康检查的西班牙工人进行了一项横断面研究。使用生物电阻抗分析确定代谢年龄，并计算可避免生命损失年数（ALLY）指数，即代谢年龄与实际年龄之差。使用各种经过验证的量表评估MASLD风险，包括脂肪肝指数（FLI）、肝脂肪变性指数（HSI）、浙江大学指数（ZJU）、脂肪性肝病指数（FLD）和脂质积聚产物（LAP）。进行多项逻辑回归分析，以检验代谢年龄与MASLD风险评分之间的关联，并对社会人口统计学和生活方式变量进行调整。：在所有评估量表中，MASLD风险较高的个体代谢年龄值更高。女性的平均代谢年龄始终低于男性，且这些差异具有统计学意义（<0.01）。多项逻辑回归分析显示，与代谢年龄增加关联最强的是MASLD风险评分、身体不活动和对地中海饮食的依从性差。ROC曲线分析表明，FLD（女性AUC：0.935，男性AUC：0.917）和FLI（女性AUC：0.900，男性AUC：0.833）具有较高的预测能力，尤登指数值较高。：代谢年龄与MASLD风险显著相关，表明其作为识别代谢性肝病高风险个体的非侵入性生物标志物的潜力。包括身体活动和饮食模式在内的生活方式因素在调节代谢年龄方面起着关键作用，凸显了针对MASLD预防进行有针对性干预的重要性。有必要进一步研究以验证代谢年龄作为MASLD风险评估中的预后工具。
