Aboeleneen Sara B, Scully Mackenzie A, Harris Jenna C, Sterin Eric H, Day Emily S
Biomedical Engineering, University of Delaware, Newark, DE, USA.
Materials Science and Engineering, University of Delaware, Newark, DE, USA.
Nano Converg. 2022 Aug 12;9(1):37. doi: 10.1186/s40580-022-00328-4.
Cancer is a global health problem that needs effective treatment strategies. Conventional treatments for solid-tumor cancers are unsatisfactory because they cause unintended harm to healthy tissues and are susceptible to cancer cell resistance. Nanoparticle-mediated photothermal therapy is a minimally invasive treatment for solid-tumor cancers that has immense promise as a standalone therapy or adjuvant to other treatments like chemotherapy, immunotherapy, or radiotherapy. To maximize the success of photothermal therapy, light-responsive nanoparticles can be camouflaged with cell membranes to endow them with unique biointerfacing capabilities that reduce opsonization, prolong systemic circulation, and improve tumor delivery through enhanced passive accumulation or homotypic targeting. This ensures a sufficient dose of photoresponsive nanoparticles arrives at tumor sites to enable their complete thermal ablation. This review summarizes the state-of-the-art in cell membrane camouflaged nanoparticles for photothermal cancer therapy and provides insights to the path forward for clinical translation.
癌症是一个全球性的健康问题，需要有效的治疗策略。实体肿瘤癌症的传统治疗方法并不理想，因为它们会对健康组织造成意外损害，并且容易产生癌细胞耐药性。纳米颗粒介导的光热疗法是一种针对实体肿瘤癌症的微创治疗方法，作为一种独立疗法或化疗、免疫疗法、放疗等其他治疗方法的辅助手段，具有巨大的前景。为了最大限度地提高光热疗法的成功率，光响应纳米颗粒可以用细胞膜进行伪装，赋予它们独特的生物界面能力，从而减少调理作用、延长全身循环时间，并通过增强被动积累或同型靶向作用来改善肿瘤递送。这确保了足够剂量的光响应纳米颗粒到达肿瘤部位，以实现其完全热消融。本综述总结了用于光热癌症治疗的细胞膜伪装纳米颗粒的最新进展，并为临床转化的前进道路提供了见解。
