Sun Xiaoya, Zhang Zhenao, Ren Jingyi, Pei Huanting, Liu Jie, Yin Bowen, Zhang Chongyue, Wen Rui, Qiao Simeng, Wang Ziyi, Ma Yuxia
Hebei Key Laboratory of Environment and Human Health, Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Shijiazhuang 050017, China.
Toxics. 2025 Apr 23;13(5):328. doi: 10.3390/toxics13050328.
Air pollution is closely associated with the development of multiple metabolic diseases. Circadian syndrome (CircS), as an extended concept of metabolic syndrome (MetS), has been proven to be a better predictor of metabolic diseases than MetS. However, the relationship between volatile organic compounds (VOCs) and CircS in pre- and postmenopausal women remains unclear. This study used data from the National Health and Nutrition Examination Survey (NHANES) 2011-2020, including 520 premenopausal women and 531 postmenopausal women. Generalized linear model (GLM), restricted cubic spline (RCS) model, subgroup analyses, and weighted quantile sum (WQS) model were used to assess the relationship between VOCs and CircS. In addition, sensitivity analyses were performed to evaluate the robustness of the results. Our findings showed that seven VOC metabolites were positively associated with the risk of CircS in postmenopausal women. In premenopausal women, only two VOC metabolites were positively associated with the risk of CircS. The WQS analysis further confirmed that VOC mixtures selected by a least absolute shrinkage and selection operator (LASSO) were significantly associated with an increased risk of CircS in postmenopausal women, with HPMMA identified as the primary contributor to the combined effect. This association was not evident in premenopausal women. Meanwhile, in postmenopausal women, individual urinary VOC metabolites and VOC mixtures were observed to be positively associated with elevated glucose and short sleep. Our results highlighted that VOC exposure was strongly associated with the occurrence of CircS in postmenopausal women. Further research is needed to confirm this conclusion.
空气污染与多种代谢性疾病的发展密切相关。昼夜节律综合征（CircS）作为代谢综合征（MetS）的一个扩展概念，已被证明比MetS更能预测代谢性疾病。然而，绝经前后女性体内挥发性有机化合物（VOCs）与CircS之间的关系仍不清楚。本研究使用了2011 - 2020年美国国家健康与营养检查调查（NHANES）的数据，其中包括520名绝经前女性和531名绝经后女性。采用广义线性模型（GLM）、受限立方样条（RCS）模型、亚组分析和加权分位数和（WQS）模型来评估VOCs与CircS之间的关系。此外，还进行了敏感性分析以评估结果的稳健性。我们的研究结果表明，七种VOC代谢物与绝经后女性CircS风险呈正相关。在绝经前女性中，只有两种VOC代谢物与CircS风险呈正相关。WQS分析进一步证实，通过最小绝对收缩和选择算子（LASSO）选择的VOC混合物与绝经后女性CircS风险增加显著相关，其中HPMMA被确定为联合效应的主要贡献者。这种关联在绝经前女性中不明显。同时，在绝经后女性中，观察到个体尿液VOC代谢物和VOC混合物与血糖升高和睡眠不足呈正相关。我们的结果强调，VOC暴露与绝经后女性CircS的发生密切相关。需要进一步的研究来证实这一结论。
