Huang Bilu, Hu Xiaowen
Aging Dis. 2025 May 20. doi: 10.14336/AD.2025.0541.
This article emphasizes the causal relationship in the mechanisms of aging, asserting that among the twelve hallmarks of aging, only telomere shortening is the cause of aging. The "Telomere DNA and ribosomal DNA co-regulation model for cell senescence" suggests that the shortening of telomeres and rDNA arrays can mediate various hallmarks of aging through the P53 pathway. Therefore, the best way to reverse aging and significantly extend lifespan is to increase the length of telomeres and rDNA arrays in adult stem cells within tissues.
本文强调衰老机制中的因果关系，断言在衰老的十二个标志中，只有端粒缩短是衰老的原因。“细胞衰老的端粒DNA与核糖体DNA共同调控模型”表明，端粒和核糖体DNA阵列的缩短可通过P53途径介导衰老的各种标志。因此，逆转衰老并显著延长寿命的最佳方法是增加组织内成体干细胞中端粒和核糖体DNA阵列的长度。
