Sharif Razinah, Wai Mah Kit, Choon Ooi Theng, Abdul Hafid Sitti Rahma, Lee Tze Yan
Centre for Healthy Ageing and Wellness, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, Kuala Lumpur 50300, Malaysia.
Premier Integrated Labs Sdn. Bhd., Kuala Lumpur 55100, Malaysia.
Nutrients. 2025 Jun 30;17(13):2179. doi: 10.3390/nu17132179.
This study investigates the effects of a tocotrienol-enriched drink on oxidative damage and genomic stability in older adults over a 6-month period. A total of 67 participants (27 males and 40 females, mean age 60.45 ± 5.75 years) were enrolled in this double-blinded, two-arm, parallel randomized controlled trial. Baseline, mid-point, and end-point assessments were conducted to monitor various health parameters. Significant Group × Time interaction effects were observed for several key outcomes. Group A demonstrated significantly better improvements in QOL-Psychological ( = 0.014, Partial Eta Squared = 0.153), suggesting a beneficial impact of tocotrienol supplementation on mental well-being. Additionally, Group A showed more favorable trends in TNF-α ( = 0.04), T-SOD ( = 0.04), catalase ( = 0.02), and telomerase ( = 0.02), suggesting potential antioxidant and genomic stability improvements over time. In a nutshell, tocotrienol supplementation may exert beneficial effects on psychological well-being, oxidative stress modulation, and genomic stability in aging populations.
本研究调查了富含生育三烯酚的饮品在6个月期间对老年人氧化损伤和基因组稳定性的影响。共有67名参与者（27名男性和40名女性，平均年龄60.45±5.75岁）被纳入这项双盲、双臂、平行随机对照试验。进行了基线、中点和终点评估以监测各种健康参数。在几个关键结果中观察到显著的组×时间交互效应。A组在生活质量-心理方面表现出显著更好的改善（P = 0.014，偏 eta 平方 = 0.153），表明补充生育三烯酚对心理健康有有益影响。此外，A组在肿瘤坏死因子-α（P = 0.04）、总超氧化物歧化酶（P = 0.04）、过氧化氢酶（P = 0.02）和端粒酶（P = 0.02）方面显示出更有利的趋势，表明随着时间的推移可能改善抗氧化和基因组稳定性。简而言之，补充生育三烯酚可能对老年人群的心理健康、氧化应激调节和基因组稳定性产生有益影响。
