Lee Saangyoung E, Brown Kevin D, Overton Andrea B, Thompson Nicholas J, Sloop Amanda D, Richter Margaret E, Canfarotta Michael W, Selleck A Morgan, Dedmon Matthew M, Dillon Margaret T
Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill.
Department of Audiology, UNC Health, Chapel Hill, North Carolina.
Otol Neurotol. 2025 Sep 1;46(8):e302-e306. doi: 10.1097/MAO.0000000000004543. Epub 2025 May 15.
Review the relationship of tonotopic mismatch with the speech recognition of cochlear implant (CI) users with unilateral hearing loss (UHL; also known as single-sided deafness).
Twenty-seven adults (≥18 yr of age) with late-onset UHL.
Cochlear implantation.
Speech recognition was assessed at 6 months post-activation with consonant-nucleus-consonant (CNC) words in the CI alone condition (contralateral ear masked). In the combined condition (CI plus the normal-hearing ear), masked speech recognition was assessed using AzBio sentences in a 10-talker masker (0-dB signal-to-noise ratio) in three target-to-masker configurations. Tonotopic mismatch was calculated as the semitone deviation between the center filter frequency and the cochlear place frequency of the most apical electrode contact.
There was a significant, negative association between tonotopic mismatch and CNC scores ( r27 = -0.43, p = 0.013) and masked speech recognition when the target was from the front and the masker was presented toward the normal-hearing ear ( r27 = -0.36, p = 0.033).
The speech recognition of adult CI users with UHL in the CI alone and bilateral listening conditions may be significantly influenced by tonotopic mismatches. These findings support the need for prospective investigation of methods to reduce or eliminate tonotopic mismatches (e.g., implantation of electrode arrays that approximate cochlear place and/or individualized mapping of filter frequencies) for CI users with UHL.
回顾音调拓扑失配与单侧听力损失（UHL，也称为单侧耳聋）的人工耳蜗（CI）使用者言语识别之间的关系。
27名成年（≥18岁）迟发性UHL患者。
人工耳蜗植入。
在激活后6个月，在仅使用CI的情况下（对侧耳掩蔽），用辅音-核-辅音（CNC）单词评估言语识别。在联合情况下（CI加正常听力耳），在三种目标-掩蔽配置中，使用AzBio句子在10说话者掩蔽器（0分贝信噪比）中评估掩蔽言语识别。音调拓扑失配计算为中心滤波器频率与最顶端电极触点的耳蜗位置频率之间的半音偏差。
音调拓扑失配与CNC得分之间存在显著的负相关（r27 = -0.43，p = 0.013），当目标来自前方且掩蔽器朝向正常听力耳呈现时，掩蔽言语识别也存在显著负相关（r27 = -0.36，p = 0.033）。
在仅使用CI和双耳聆听条件下，成年UHL CI使用者的言语识别可能会受到音调拓扑失配的显著影响。这些发现支持对减少或消除音调拓扑失配的方法（例如，植入接近耳蜗位置的电极阵列和/或滤波器频率的个性化映射）进行前瞻性研究，以造福UHL CI使用者。
