Thompson R A, Sukumaran K D, Rajagopalan K
Clin Exp Immunol. 1985 Aug;61(2):329-35.
In a study of C-reactive protein (CRP) levels in the sera of 77 patients with leprosy, it was found that in the majority of newly diagnosed patients, the level was within the normal range for a healthy Malaysian population. Elevated levels did occur, but were usually found in patients with complications, and were more likely to occur in patients who had been receiving drug treatment for some time. This suggested that Mycobacterium leprae infection by itself does not stimulate CRP synthesis and could reflect a failure of synthesis by macrophages of interleukin-1, or related molecules. This was supported by the study of an analogous acute phase protein, serum amyloid P (SAP) in mice bearing M. leprae from human sources in their hind footpads. Such mice showed no significant difference in SAP levels from control mice.
在一项对77名麻风病患者血清中C反应蛋白（CRP）水平的研究中发现，大多数新诊断患者的CRP水平处于健康马来西亚人群的正常范围内。确实会出现CRP水平升高的情况，但通常见于有并发症的患者，且更有可能出现在接受了一段时间药物治疗的患者中。这表明麻风杆菌感染本身不会刺激CRP合成，可能反映出巨噬细胞合成白细胞介素-1或相关分子失败。对后脚垫接种源自人类的麻风杆菌的小鼠体内类似急性期蛋白血清淀粉样蛋白P（SAP）的研究支持了这一观点。这类小鼠的SAP水平与对照小鼠相比无显著差异。
