血清中蛋白质SAP（淀粉样蛋白P成分）与C反应蛋白的比较临床研究
Comparative clinical study of protein SAP (amyloid P component) and C-reactive protein in serum.
作者信息
Pepys M B, Dash A C, Markham R E, Thomas H C, Williams B D, Petrie A
出版信息
Clin Exp Immunol. 1978 Apr;32(1):119-24.
Abstract
The serum concentration of protein SAP (amyloid P component) has been measured for the first time in a substantial series of normal individuals and patients with various diseases, and the results contrasted with the levels of the related protein C-reactive protein (CRP). The mean +/- s.d. concentration of protein SAP was 43 +/- 14 microgram/ml in seventy-six normal men, 33 +/- 10 microgram/ml in eighty-six normal women and 4 +/- 2 microgram/ml in thirty-six normal cord sera. Unlike CRP, whick is a major acute phase reactant, protein SAP was only slightly elevated in inflammatory and neoplastic diseases in which CRP was greatly increased. The level of protein SAP was significantly depressed in patients with hepatic disease, suggesting that its measurement might be of value in their management.
摘要
首次在大量正常个体及患有各种疾病的患者中测量了血清中蛋白SAP（淀粉样蛋白P成分）的浓度，并将结果与相关蛋白C反应蛋白（CRP）的水平进行了对比。76名正常男性中蛋白SAP的平均±标准差浓度为43±14微克/毫升，86名正常女性中为33±10微克/毫升，36份正常脐带血清中为4±2微克/毫升。与作为主要急性期反应物的CRP不同，在CRP大幅升高的炎症和肿瘤性疾病中，蛋白SAP仅略有升高。肝病患者的蛋白SAP水平显著降低，这表明对其进行测量可能对肝病的治疗有价值。
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