NR2F6作为预后不良的指标，促进神经母细胞瘤的恶性进展。
NR2F6 promotes the malignant progression of neuroblastoma as an indicator of poor prognosis.
作者信息
Liu Yimeng, Zhang Zhaoxia, Mi Tao, Jin Liming, Wang Zhaoying, Li Mujie, Wang Jinkui, Wu Xin, Luo Junyi, Liu Jiayan, Ren Chunnian, He Dawei
机构信息
Department of Urology, Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, International Science and Technology Cooperation Base of Child Development and Critical Disorders, Chongqing, P.R China.
Chongqing Key Laboratory of Children Urogenital Development and Tissue Engineering, Chongqing, P.R China.
出版信息
PLoS One. 2025 May 27;20(5):e0324334. doi: 10.1371/journal.pone.0324334. eCollection 2025.
BACKGROUND
NR2F6 is an orphan nuclear receptor with dual tumorigenic activity in the immune system and tumor cells, playing an essential role in tumor differentiation and immunity. This study aimed to investigate the expression level of NR2F6 in various tumors and its effect on neuroblastoma (NB).
METHODS
We evaluated the role of NR2F6 in the genesis and development of 34 different tumors through multiple databases. In addition, we investigated the effects of NR2F6 expression levels on NB risk factors and prognosis using pathology sections and clinical data from primary retroperitoneal NB in children. The effects on cell proliferation, invasion, and migration were explored by knocking down NR2F6 expression in SK-N-BE(2) and SK-N-SH cells.
RESULTS
The findings showed that NR2F6 was significantly correlated with the prognosis of NB and was an important indicator suggesting disease regression. In addition, NR2F6 knockdown slowed down NB cells' proliferation, invasion, and migration ability in vitro.
CONCLUSION
Our results suggest that NR2F6 plays a crucial role in tumor-promoting effects and can be used as a potential prognostic marker for NB.
背景
NR2F6是一种孤儿核受体，在免疫系统和肿瘤细胞中具有双重致瘤活性，在肿瘤分化和免疫中起重要作用。本研究旨在探讨NR2F6在各种肿瘤中的表达水平及其对神经母细胞瘤（NB）的影响。
方法
我们通过多个数据库评估了NR2F6在34种不同肿瘤发生和发展中的作用。此外，我们利用儿童原发性腹膜后NB的病理切片和临床数据，研究了NR2F6表达水平对NB危险因素和预后的影响。通过敲低SK-N-BE(2)和SK-N-SH细胞中NR2F6的表达，探讨其对细胞增殖、侵袭和迁移的影响。
结果
研究结果表明，NR2F6与NB的预后显著相关，是提示疾病消退的重要指标。此外，敲低NR2F6可减缓NB细胞在体外的增殖、侵袭和迁移能力。
结论
我们的结果表明，NR2F6在肿瘤促进作用中起关键作用，可作为NB的潜在预后标志物。
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