在艾贝尔逊病毒转化的恶性小鼠大细胞淋巴瘤中，abl及其他癌基因的表达与转移潜能无关。
Expression of abl and other oncogenes is independent of metastatic potential in Abelson virus-transformed malignant murine large cell lymphoma.
作者信息
Rotter V, Wolf D, Blick M, Nicolson G L
出版信息
Clin Exp Metastasis. 1985 Apr-Jun;3(2):77-86. doi: 10.1007/BF01758957.
The role of oncogene expression in tumor metastasis was examined using the Abelson leukemia virus-transformed murine large cell lymphoma RAW117. Cell sublines of low and high metastatic potential expressed equally abl oncogene-coded mRNA and its phosphoprotein product p160, and the capacity of p160 to become autophosphorylated with gamma-[32P]ATP was the same among low and high metastatic cells. The expression of other oncogene-coded mRNAs (fos, myc, myb), if present, was also similar in low and high metastatic RAW117 cells. Although oncogene expression is thought to be important in initiating, and in some cases maintaining, the transformed phenotype, its expression in RAW117 lymphoma cells appears to be unrelated to metastatic phenotype.
利用阿贝尔森白血病病毒转化的小鼠大细胞淋巴瘤RAW117，研究了癌基因表达在肿瘤转移中的作用。低转移潜能和高转移潜能的细胞亚系表达等量的abl癌基因编码的mRNA及其磷蛋白产物p160，并且在低转移和高转移细胞中，p160被γ-[32P]ATP自身磷酸化的能力相同。在低转移和高转移的RAW117细胞中，其他癌基因编码的mRNA（fos、myc、myb）的表达（如果存在）也相似。虽然癌基因表达被认为在启动并在某些情况下维持转化表型方面很重要，但其在RAW117淋巴瘤细胞中的表达似乎与转移表型无关。
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