Slager U T, Hsu J D, Jordan C
Clin Orthop Relat Res. 1985 Oct(199):159-68.
There is little information on the muscle fiber changes or the fiber type affected in supraspinal hemiplegia. Muscle biopsy specimens from 20 patients with stroke, obtained during orthopedic reconstruction, were examined by modern histochemistry. Atrophy was present in all of the muscles, affecting Type 1 fibers in 100% and Type 2 fibers in 95% of the patients. Type 2 atrophy was more severe than Type 1 atrophy. Group atrophy and fiber type grouping, present in 40%, seemed related to peripheral nerve or root damage. Hypertrophy of Type 1 fibers was present in 45%, associated with Type 2 hypertrophy in 15%. Although diffuse morphometric atrophic seemed not to correlate with the level of motor activity in this group of 20 patients, hypertrophy appeared related to activity. Hence, efforts to mobilize and rehabilitate stroke patients cannot prevent atrophy of some fibers, they seem to stimulate a hypertrophy not seen in inactive patients.
关于脊髓上性偏瘫中肌纤维变化或受影响的纤维类型的信息很少。对20例中风患者在骨科重建过程中获取的肌肉活检标本进行了现代组织化学检查。所有肌肉均出现萎缩，100%的患者1型纤维受到影响，95%的患者2型纤维受到影响。2型萎缩比1型萎缩更严重。40%的患者出现群组萎缩和纤维类型群组化，这似乎与周围神经或神经根损伤有关。45%的患者出现1型纤维肥大，其中15%伴有2型纤维肥大。尽管在这20例患者中，弥漫性形态计量学萎缩似乎与运动活动水平无关，但肥大似乎与活动有关。因此，动员和康复中风患者的努力虽然无法防止某些纤维萎缩，但似乎能刺激非活动患者中未出现的肥大。
