Miller M M, Patterson R
Int Arch Allergy Appl Immunol. 1977;53(4):349-56. doi: 10.1159/000231771.
Bronchial airway reactivity to carbachol (CAR) and physostigmine (PHY) was individually measured in three rhesus monkeys with and three rhesus monkeys without reagin-mediated respiratory responses (RR). The three monkeys with reagin-mediated RR demonstrated bronchial hyperreactivity to CAR (p less than 0.25) but not PHY when compared with the three control monkeys. No correlation between airway reactivity to CAR and PHY was noted in all six monkeys. We conclude that monkeys with reagin-mediated RR possess airway hyperreactivity to the exogenously administered acetylcholine analogue CAR, but not to the endogenous acetylcholine which is released in vivo by PHY.
分别在三只具有反应素介导的呼吸反应（RR）的恒河猴和三只没有反应素介导的呼吸反应的恒河猴中测量了支气管气道对卡巴胆碱（CAR）和毒扁豆碱（PHY）的反应性。与三只对照猴相比，三只具有反应素介导的RR的猴子对CAR表现出支气管高反应性（p小于0.25），但对PHY没有。在所有六只猴子中均未发现气道对CAR和PHY的反应性之间存在相关性。我们得出结论，具有反应素介导的RR的猴子对外源性给予的乙酰胆碱类似物CAR具有气道高反应性，但对PHY在体内释放的内源性乙酰胆碱没有气道高反应性。
